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Correction to Welch and Loscalzo, N Engl J Med 338(15):1042-1050 April 9, 1998.

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Volume 339:477-479 August 13, 1998 Number 7
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Homocyst(e)ine and Atherothrombosis

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by Welch, G. N.
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by Welch, G. N.
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To the Editor: The review article "Homocysteine and Atherothrombosis" by Welch and Loscalzo (April 9 issue)1 was very interesting, and it conclusively showed that elevated homocysteine levels are indeed a risk factor for vascular disease. However, the mechanism of the metabolism of homocyst(e)ine in Figure 1 of the article is incorrect in several respects. Specifically, the chemical structures of homocysteine and glutathione are incorrect. The enzyme cystathionine {beta}-synthase is in the wrong step of the proposed pathway, and the enzyme cystathioninase is not included at all.

The structure of homocysteine is missing one carbon in its backbone. Homocysteine is a . . . [Full Text of this Article]

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