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Previous Volume 339:578-583 August 27, 1998 Number 9 Next

	Full Text PDF Editorial by Adamson, J. W. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Several studies have suggested that if recombinant human erythropoietin (epoetin) is administered subcutaneously rather than intravenously, a lower dose may be sufficient to maintain the hematocrit at a given level.

Methods In a randomized, unblinded trial conducted at 24 hemodialysis units at Veterans Affairs medical centers, we assigned 208 patients who were receiving long-term hemodialysis and epoetin therapy to treatment with either subcutaneous or intravenous epoetin. The dose was initially reduced until the hematocrit was below 30 percent and then was gradually increased to a level that would maintain the hematocrit in the range of 30 to 33 percent for 26 weeks. We compared the average doses in the 26-week maintenance phase and the discomfort associated with the two routes of administration.

Results For the 107 patients treated by the subcutaneous route, the average weekly dose of epoetin during the maintenance phase was 32 percent less than that for the 101 patients treated by the intravenous route (mean [±SD], 95.1±75.0 vs. 140.3±88.5 U per kilogram of body weight per week; P<0.001). Only one patient in the subcutaneous-therapy group withdrew from the study because of pain at the injection site, and 86 percent rated the pain associated with subcutaneous administration as ranging from absent to mild.

Conclusions In patients receiving hemodialysis, subcutaneous administration of epoetin can maintain the hematocrit in a desired target range, with an average weekly dose of epoetin that is lower than with intravenous administration.

Source Information

From the Boston Veterans Affairs Medical Center and Department of Medicine, Boston University School of Medicine, Boston (J.S.K.); the Veterans Affairs Cooperative Studies Program Coordinating Center, Hines, Ill. (D.J.R., W.G.H.); the Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, N.M. (C.L.F.); New York Veterans Affairs Medical Center and the Department of Medicine, New York University School of Medicine, New York (D.S.G.); Milwaukee Veterans Affairs Medical Center and the Department of Medicine, Medical College of Wisconsin, Milwaukee (J.G.K.); and Miami Veterans Affairs Medical Center and the Department of Medicine, University of Miami School of Medicine, Miami (C.A.V.).

Address reprint requests to Dr. Kaufman at the Renal Section (111-RE), Boston Veterans Affairs Medical Center, 150 S. Huntington Ave., Boston, MA 02130.

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