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Correspondence
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Volume 340:809-812 March 11, 1999 Number 10
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Hematopoietic Stem-Cell Transplantation for Acute Leukemia

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by Sasazuki, T.
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by Aversa, F.
To the Editor: Sasazuki et al. (Oct. 22 issue)1 report increased survival at one year among patients who underwent transplantation of hematopoietic stem cells from unrelated donors that was associated with matching of HLA-A alleles. They do not report the effect of isolated HLA-A mismatches. Thus, the effect of HLA-A mismatches could be due to multiple mismatches of linked HLA-C, B, and DRB1 alleles.


Thomas H. Eiermann, M.D., Ph.D.
University Hospital Eppendorf
20246 Hamburg, Germany

References

  1. Sasazuki T, Juji T, Morishima Y, et al. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. N Engl J Med 1998;339:1177-1185. [Free Full Text]
 
To the Editor: The October 22 issue contains important and well-reported studies by Sasazuki et al. and Aversa et al.,1 as well as an accompanying . . . [Full Text of this Article]

References



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