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Original Article
Brief Report
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Volume 340:852-856 March 18, 1999 Number 11
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Impaired Counterregulation of Glucose in a Patient with Hypothalamic Sarcoidosis
Françoise Féry, M.D., Ph.D., Laurence Plat, M.D., Philippe van de Borne, M.D., Ph.D., Elie Cogan, M.D., Ph.D., and Jean Mockel, M.D., Ph.D.

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Hypoglycemia stimulates rapid increases in the secretion of several hormones, including catecholamines, glucagon, cortisol, and growth hormone, that act in concert to increase the plasma glucose concentration. The chief role of the central nervous system in triggering the release of such counterregulatory hormones during hypoglycemia is well recognized. The specific region of the hypothalamus responsible for this process is probably the ventromedial region, because bilateral lesions or perfusion of d-glucose into this region reduces the increases in plasma glucagon and catecholamines in response to hypoglycemia in rats.1,2 We describe a patient with a hypothalamic sarcoid infiltrate who had complete loss . . . [Full Text of this Article]

Case Report

Methods

Results

Base-Line Hormonal Status

Glucose Homeostasis

Effect of Acute Hypoglycemia on the Release of Counterregulatory Hormones

Effect of a Hypoglycemic Clamp on the Release of Counterregulatory Hormones

Changes in Muscle Sympathetic-Nerve Activity in Response to Hypoglycemia, Chemoreceptor-Reflex Activation, and Baroreflex Deactivation

Release of Counterregulatory Hormones in Response to Other Stimuli

Other Tests

Discussion


Source Information

From the Departments of Endocrinology (F.F., L.P., J.M.) and Internal Medicine (E.C.) and the Hypertension Clinic (P.B.), Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Address reprint requests to Dr. Féry at the Department of Endocrinology, Hôpital Erasme, 808 route de Lennik, B-1070 Brussels, Belgium, or at ffery@med.ulb.ac.be.

References


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