Hypoglycemia stimulates rapid increases in the secretion ofseveral hormones, including catecholamines, glucagon, cortisol,and growth hormone, that act in concert to increase the plasmaglucose concentration. The chief role of the central nervoussystem in triggering the release of such counterregulatory hormonesduring hypoglycemia is well recognized. The specific regionof the hypothalamus responsible for this process is probablythe ventromedial region, because bilateral lesions or perfusionof d-glucose into this region reduces the increases in plasmaglucagon and catecholamines in response to hypoglycemia in rats.1,2We describe a patient with a hypothalamic sarcoid infiltratewho had complete loss . . . [Full Text of this Article]
Case Report
Methods
Results
Base-Line Hormonal Status
Glucose Homeostasis
Effect of Acute Hypoglycemia on the Release of Counterregulatory Hormones
Effect of a Hypoglycemic Clamp on the Release of Counterregulatory Hormones
Changes in Muscle Sympathetic-Nerve Activity in Response to Hypoglycemia, Chemoreceptor-Reflex Activation, and Baroreflex Deactivation
Release of Counterregulatory Hormones in Response to Other Stimuli
Other Tests
Discussion
Source Information
From the Departments of Endocrinology (F.F., L.P., J.M.) and Internal Medicine (E.C.) and the Hypertension Clinic (P.B.), Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Address reprint requests to Dr. Féry at the Department of Endocrinology, Hôpital Erasme, 808 route de Lennik, B-1070 Brussels, Belgium, or at ffery@med.ulb.ac.be.
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