FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 340:878-879 March 18, 1999 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Lagergren, J. PubMed Citation

Heartburn is a serious symptom that merits more attention from patients and physicians. It is the hallmark of gastroesophageal reflux, a disorder that may lead to esophagitis, progressing in some patients to the metaplastic columnar mucosal changes known as Barrett's esophagus, and ultimately to adenocarcinoma.

Since the 1970s, the incidence of adenocarcinomas of the esophagus and gastric cardia has risen more rapidly than the incidence of any other cancer in the United States. During this time, the incidence of esophageal adenocarcinoma has increased by a factor of six to eight, with little change in the incidence of esophageal squamous-cell carcinoma. . . . [Full Text of this Article]

References

Related Letters:

Gastroesophageal Reflux and Adenocarcinoma of the Esophagus
Nandurkar S., Talley N. J., Heath E. I., Holbrook J. T., Forastiere A. A., Marcus G., Marshall K. G., Gofman J. W., Lagergren J., Nyrén O.
Extract | Full Text  
N Engl J Med 1999; 341:536-538, Aug 12, 1999. Correspondence

This article has been cited by other articles:

• Solaymani-Dodaran, M, Logan, R F A, West, J, Card, T, Coupland, C (2004). Risk of oesophageal cancer in Barrett's oesophagus and gastro-oesophageal reflux. Gut 53: 1070-1074 [Abstract] [Full Text]  
• Bateman, D N, Colin-Jones, D, Hartz, S, Langman, M, Logan, R F, Mant, J, Murphy, M, Paterson, K R, Rowsell, R, Thomas, S, Vessey, M (2003). Mortality study of 18 000 patients treated with omeprazole. Gut 52: 942-946 [Abstract] [Full Text]  
• Lagergren, J., Ye, W., Bergstrom, R., Nyren, O. (2000). Utility of Endoscopic Screening for Upper Gastrointestinal Adenocarcinoma. JAMA 284: 961-962 [Full Text]  
• Richter, J. E., Peura, D., Benjamin, S. B., Joelsson, B., Whipple, J. (2000). Efficacy of Omeprazole for the Treatment of Symptomatic Acid Reflux Disease Without Esophagitis. Arch Intern Med 160: 1810-1816 [Abstract] [Full Text]  
• Johnston, B. T. (2000). The significance of heartburn. QJM 93: 321-322 [Full Text]  
• Nandurkar, S., Talley, N. J., Heath, E. I., Holbrook, J. T., Forastiere, A. A., Marcus, G., Marshall, K. G., Gofman, J. W., Lagergren, J., Nyren, O. (1999). Gastroesophageal Reflux and Adenocarcinoma of the Esophagus. NEJM 341: 536-538 [Full Text]