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Previous Volume 340:1043-1045 April 1, 1999 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Soignet, S. L.

To the Editor: Soignet et al. (Nov. 5 issue)¹ report the induction of complete remissions in patients with acute promyelocytic leukemia after treatment with low doses of arsenic trioxide. They conclude, "The clinical response is associated with incomplete cytodifferentiation and the induction of apoptosis with caspase activation in leukemic cells." Since the latter point is one of the major novelties discussed in the article, we would like to comment on this conclusion.

The authors apparently analyzed bone marrow from one patient to make the point that arsenic induces apoptosis in leukemic cells in vivo. The analysis of all mononuclear cells . . . [Full Text of this Article]

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