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Correspondence
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Volume 340:1123 April 8, 1999 Number 14
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Case 35-1998: Use of Lithium to Prevent Corticosteroid-Induced Mania

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To the Editor: I was surprised to read that a physician caring for the patient described in Case 35-1998 (Nov. 19 issue)1 administered lithium to prevent corticosteroid-induced manic symptoms. No reference was given for this intervention, and lithium itself can cause central nervous system side effects. Several reviews of the central nervous system side effects of corticosteroids mention the possible value of the prophylactic administration of lithium.2,3,4 These reviews all cite the same study,5 an interesting report on the effects of lithium in a cohort of patients treated with corticotropin for multiple sclerosis. In this study, lithium-treated patients were compared . . . [Full Text of this Article]

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