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Correspondence
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Volume 340:1292-1293 April 22, 1999 Number 16
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Terbinafine and Fulminant Hepatic Failure

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To the Editor: Terbinafine is an antifungal agent that is widely prescribed for common skin infections.1 We describe a patient who had taken terbinafine and in whom fulminant hepatic failure developed, requiring orthotopic liver transplantation.

A 48-year-old woman took 250 mg of terbinafine daily for five days for a fungal nail infection. Over the next four weeks, fulminant hepatic failure developed. The patient had been taking dothiepin (75 mg per day), which is a tricyclic antidepressant, and propranolol (40 mg twice daily) for more than 18 months. She had no risk factors for liver disease, a minimal intake of alcohol . . . [Full Text of this Article]

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