Skin cancers, predominantly basal-cell and squamous-cell carcinomas,have accounted for an estimated 40 percent of all cancers inthe United States in recent years, and their frequency has beenincreasing.1,2 The frequency of malignant melanoma, by far themost common fatal skin cancer, has also increased, by a factorof approximately 15 in the past 60 years.3,4,5 In 1997, morethan 40,000 new cases of malignant melanoma were diagnosed inthe United States, and more than 7200 patients with the diseasedied.1 Moreover, malignant melanoma is one of the most commoncancers in young adults.6 Efforts to educate primary care . . . [Full Text of this Article]
Ultraviolet Radiation as a Risk Factor for Melanoma
Epidemiologic Features of Photocarcinogenesis
The Photoprotective Role of Melanocytes
Homeostasis of Melanocytes
Induction of the Capacity to Repair DNA by Ultraviolet Radiation
Implications for the Epidemiology of Melanoma
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From the Department of Dermatology, Boston University School of Medicine, Boston.
Address reprint requests to Dr. Gilchrest at the Department of Dermatology, Boston University School of Medicine, 609 Albany St., Boston, MA 02118, or at bgilchre@bu.edu.
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