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Review Article
Mechanisms of Disease
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Volume 340:1341-1348 April 29, 1999 Number 17
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The Pathogenesis of Melanoma Induced by Ultraviolet Radiation
Barbara A. Gilchrest, M.D., Mark S. Eller, Ph.D., Alan C. Geller, R.N., M.P.H., and Mina Yaar, M.D.

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Skin cancers, predominantly basal-cell and squamous-cell carcinomas, have accounted for an estimated 40 percent of all cancers in the United States in recent years, and their frequency has been increasing.1,2 The frequency of malignant melanoma, by far the most common fatal skin cancer, has also increased, by a factor of approximately 15 in the past 60 years.3,4,5 In 1997, more than 40,000 new cases of malignant melanoma were diagnosed in the United States, and more than 7200 patients with the disease died.1 Moreover, malignant melanoma is one of the most common cancers in young adults.6 Efforts to educate primary care . . . [Full Text of this Article]

Ultraviolet Radiation as a Risk Factor for Melanoma

Epidemiologic Features of Photocarcinogenesis

The Photoprotective Role of Melanocytes

Homeostasis of Melanocytes

Induction of the Capacity to Repair DNA by Ultraviolet Radiation

Implications for the Epidemiology of Melanoma


Source Information

From the Department of Dermatology, Boston University School of Medicine, Boston.

Address reprint requests to Dr. Gilchrest at the Department of Dermatology, Boston University School of Medicine, 609 Albany St., Boston, MA 02118, or at bgilchre@bu.edu.

References


Related Letters:

The Pathogenesis of Melanoma Induced by Ultraviolet Radiation
Mack T., Whiteman D., Green A., Gilchrest B. A., Geller A. C.
Extract | Full Text  
N Engl J Med 1999; 341:766-767, Sep 2, 1999. Correspondence

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