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Previous Volume 340:1412-1417 May 6, 1999 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Acute pancreatitis may be clinically mild or severe. Severe acute pancreatitis is usually a result of pancreatic glandular necrosis. The morbidity and mortality associated with acute pancreatitis are substantially higher when necrosis is present, especially when the area of necrosis is also infected.¹ It is important to identify patients with pancreatic necrosis so that appropriate management can be undertaken. In recent years, the treatment of these patients has shifted away from early surgical débridement ("necrosectomy") to aggressive intensive medical care, with specific criteria for operative and nonoperative intervention.^2,3 Advances in radiologic imaging and aggressive medical management with emphasis on the . . . [Full Text of this Article]

Presentation and Classification

Recognition of Pancreatic Necrosis

Management of Infection

Endoscopic Retrograde Cholangiopancreatography

Nutritional Support

Interventions for Pancreatic Necrosis

Surgical Débridement

Alternative Methods of Débridement

Percutaneous Therapy (Interventional Radiology)

Endoscopic Therapy

Long-Term Sequelae

Future Medical Therapies

Conclusions

Source Information

From the Departments of Medicine, Divisions of Gastroenterology and Hepatology, Mayo Medical School, Rochester, Minn., and the University of Alabama, Birmingham (T.H.B.); and the Department of Radiology, University of Alabama, Birmingham (D.E.M.).

Address reprint requests to Dr. Baron at the Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, or at baron.todd@mayo.edu.

References

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• Bluth, M., Lin, Y.-y., Zhang, H., Viterbo, D., Zenilman, M. (2008). Use of Gene Expression Profiles in Cells of Peripheral Blood to Identify New Molecular Markers of Acute Pancreatitis. Arch Surg 143: 227-233 [Abstract] [Full Text]  
• Sandrasegaran, K., Tann, M., Jennings, S. G., Maglinte, D. D., Peter, S. D., Sherman, S., Howard, T. J. (2007). Disconnection of the Pancreatic Duct: An Important But Overlooked Complication of Severe Acute Pancreatitis. RadioGraphics 27: 1389-1400 [Abstract] [Full Text]  
• Matsuda, N., Nishihira, J., Takahashi, Y., Kemmotsu, O., Hattori, Y. (2006). Role of Macrophage Migration Inhibitory Factor in Acute Lung Injury in Mice with Acute Pancreatitis Complicated by Endotoxemia. Am. J. Respir. Cell Mol. Bio. 35: 198-205 [Abstract] [Full Text]  
• McClave, S. A., Chang, W.-K., Dhaliwal, R., Heyland, D. K. (2006). Nutrition Support in Acute Pancreatitis: A Systematic Review of the Literature. JPEN J Parenter Enteral Nutr 30: 143-156 [Abstract] [Full Text]  
• Rickes, S, Uhle, C, Kahl, S, Kolfenbach, S, Monkemuller, K, Effenberger, O, Malfertheiner, P (2006). Echo enhanced ultrasound: a new valid initial imaging approach for severe acute pancreatitis. Gut 55: 74-78 [Abstract] [Full Text]  
• West, J. H., Vogel, S. B., Drane, W. E. (2002). Gallium Uptake in Complicated Pancreatitis: A Predictor of Infection. Am. J. Roentgenol. 178: 841-846 [Abstract] [Full Text]  
• PRATT, D. S., EPSTEIN, S. K. (2000). Recent Advances in Critical Care Gastroenterology. Am. J. Respir. Crit. Care Med. 161: 1417-1420 [Full Text]  
• Gore, R. M., Miller, F. H., Pereles, F. S., Yaghmai, V., Berlin, J. W. (2000). Helical CT in the Evaluation of the Acute Abdomen. Am. J. Roentgenol. 174: 901-913 [Full Text]