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Volume 340:1436-1439 May 6, 1999 Number 18
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Treatment of Acute Myeloid Leukemia

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To the Editor: Cassileth et al. (Dec. 3 issue)1 report the results of a large study comparing chemotherapy with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission. Their study showed that autologous or allogeneic bone marrow transplantation offered no advantage over intensive chemotherapy in terms of overall survival. However, the study included patients with a variety of risk factors. Although there is no established prognostic index for acute myeloid leukemia, we believe that most institutions do not perform bone marrow transplantation in patients with either the M2 or the M3 type of . . . [Full Text of this Article]

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