Atherosclerosis is an inflammatory disease. Because high plasmaconcentrations of cholesterol, in particular those of low-densitylipoprotein (LDL) cholesterol, are one of the principal riskfactors for atherosclerosis,1 the process of atherogenesis hasbeen considered by many to consist largely of the accumulationof lipids within the artery wall; however, it is much more thanthat. Despite changes in lifestyle and the use of new pharmacologicapproaches to lower plasma cholesterol concentrations,2,3 cardiovasculardisease continues to be the principal cause of death in theUnited States, Europe, and much of Asia.4,5 In fact, the lesionsof atherosclerosis represent a series . . . [Full Text of this Article]
Factors That Induce and Promote Inflammation or Atherogenesis
Hypercholesterolemia and Modified Lipids and Lipoproteins
Homocysteine
Hypertension
Infection
The Nature of the Inflammatory Response
Interactions among Endothelial Cells, Monocytes, and T Cells
Monocytes and Immunity
Platelets
Atherosclerosis in Relation to Other Chronic Inflammatory Diseases
Inflammatory Response
Instability and Rupture of Plaque
New Perspectives on the Formation and Progression of Lesions
Smooth Muscle
The Role of the Matrix
Conclusions
Source Information
From the Department of Pathology, University of Washington School of Medicine, Box 357470, Seattle, WA 98195-7470, where reprint requests should be addressed to Dr. Ross (e-mail: rross@u.washington.edu).
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Aslim, E., Hakki Akay, T., Basturk, B., Ozkan, S., Gultekin, B., Ozcobanoglu, S., Sirvan, S., Aslamaci, S.
(2008). The Role of Antiendothelial Cell Antibodies in the Development and Follow-up of Coronary and Peripheral Arterial Diseases. ANGIOLOGY
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Cartier, A., Lemieux, I., Almeras, N., Tremblay, A., Bergeron, J., Despres, J.-P.
(2008). Visceral Obesity and Plasma Glucose-Insulin Homeostasis: Contributions of Interleukin-6 and Tumor Necrosis Factor-{alpha} in Men. J. Clin. Endocrinol. Metab.
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Li, N.
(2008). Platelet-lymphocyte cross-talk. J. Leukoc. Biol.
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Wannamethee, S. G., Sattar, N., Rumley, A., Whincup, P. H., Lennon, L., Lowe, G. D.O.
(2008). Tissue Plasminogen Activator, von Willebrand Factor, and Risk of Type 2 Diabetes in Older Men. Diabetes Care
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Linden, E., Cai, W., He, J. C., Xue, C., Li, Z., Winston, J., Vlassara, H., Uribarri, J.
(2008). Endothelial Dysfunction in Patients with Chronic Kidney Disease Results from Advanced Glycation End Products (AGE)-Mediated Inhibition of Endothelial Nitric Oxide Synthase through RAGE Activation. CJASN
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Freiberg, J. J., Tybjaerg-Hansen, A., Sillesen, H., Jensen, G. B., Nordestgaard, B. G.
(2008). Promotor Polymorphisms in Leukotriene C4 Synthase and Risk of Ischemic Cerebrovascular Disease. Arterioscler. Thromb. Vasc. Bio.
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Doran, A. C., Meller, N., McNamara, C. A.
(2008). Role of Smooth Muscle Cells in the Initiation and Early Progression of Atherosclerosis. Arterioscler. Thromb. Vasc. Bio.
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Leong, T., Zylberstein, D., Graham, I., Lissner, L., Ward, D., Fogarty, J., Bengtsson, C., Bjorkelund, C., Thelle, D., for The Swedish-Irish-Norwegian (SIN) Collaboratio,
(2008). Asymmetric Dimethylarginine Independently Predicts Fatal and Nonfatal Myocardial Infarction and Stroke in Women: 24-Year Follow-Up of the Population Study of Women in Gothenburg. Arterioscler. Thromb. Vasc. Bio.
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