In the United States, epilepsy affects approximately 0.6 percentof the population (1.6 million persons) and has a lifetime prevalenceof approximately 3 percent (and will thus affect 7.2 millionpersons).1 For the majority of patients, epileptic seizuresare controlled with a single antiepileptic drug, which may bewithdrawn when the patient has been without seizures for twoyears.2 Some patients, however, do not become completely freeof seizures even though they comply scrupulously with the prescribedregimen. Aside from having deleterious effects on health, persistentepileptic seizures have psychosocial, behavioral, and cognitiveconsequences and often impose a financial burden.3
From the Department of Neurology, New York University Medical Center, New York; and the Institute of Neurology and Neurosurgery, St. Barnabas Health Care System, Livingston, N.J.
Address reprint requests to Dr. Devinsky at the Comprehensive Epilepsy Center, Mount SinaiNYU Medical Center, 560 First Ave.Rivergate, 4th Fl., New York, NY 10016, or at od4@is4.nyu.edu.
References
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Noachtar, S., Andermann, E., Meyvisch, P., Andermann, F., Gough, W. B., Schiemann-Delgado, J., For the N166 Levetiracetam Study Group,
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10.1073/pnas.131102898v1
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342: 314-319
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