Over the past 18 years the human immunodeficiency virus type1 (HIV-1) epidemic has evolved, with the disease shifting froma syndrome whose cause was undefined to one in which the etiologicagent of AIDS was isolated and identified, but for which therapeuticoptions were limited. We are now in a new era characterizedby efficient therapeutic agents to combat HIV-1 in many patients.This progress has been based on the development of highly activeantiretroviral therapy in which combinations of agents are giventhat inhibit HIV-1 replication in vivo. Although vaccines arestill under development and critical issues such . . . [Full Text of this Article]
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