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Previous Volume 340:1756-1757 June 3, 1999 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The pathogenic effects of infection by the human immunodeficiency virus (HIV) are controlled by genes encoded by the virus and the host. One of the HIV genes, called nef, is associated with increased viral loads in animal models.¹ Nef protein promotes efficient production of virus and evasion of host immune defenses^2,3 through diverse mechanisms. The protein modulates T-cell signaling and also decreases the expression of important cell-surface proteins, including the class I histocompatibility and CD4 antigens.⁴ In this issue of the Journal, Learmont and colleagues provide insight into the natural history of infection by an attenuated virus with a mutation . . . [Full Text of this Article]

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