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Correspondence
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Volume 340:1761-1762 June 3, 1999 Number 22
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Antimicrobial-Impregnated Central Venous Catheters

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 by Darouiche, R. O.
To the Editor: Dr. Darouiche and colleagues (Jan. 7 issue)1 conclude that the use of central venous catheters impregnated with minocycline and rifampin is associated with a lower rate of catheter-related bloodstream infection than the use of catheters impregnated with chlorhexidine and silver sulfadiazine. They defined a catheter-related bloodstream infection by the isolation of the same organism from the vascular catheter and from peripheral blood in a patient with sepsis and no other apparent source of bloodstream infection. However, residual antimicrobial activity in the removed catheter sufficient to prevent growth from the cultured catheter segments would substantially reduce the apparent . . . [Full Text of this Article]

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