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Editorial
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Volume 340:1991-1993 June 24, 1999 Number 25
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Predicting Outcome in Neuroblastoma

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Neuroblastoma is a malignant tumor in children that arises from primordial neural-crest cells destined to populate the adrenal gland and sympathetic ganglia, hence its varied clinical presentation and course. It accounts for 8 to 10 percent of all childhood cancers and for 15 percent of cancer-related deaths in children.1 The distinctive nature of this neoplasm lies in its remarkable ability to resolve spontaneously while also being notoriously aggressive in older children with metastatic disease. The challenge for research on neuroblastoma over the past decade has been to improve the clinician's ability to predict the risk of relapse for any given . . . [Full Text of this Article]

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