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Correspondence
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Volume 340:238-239 January 21, 1999 Number 3
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Mutations of the Cystic Fibrosis Gene and Pancreatitis

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 by Sharer, N.
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To the Editor: In the September 3 issue, Sharer et al.1 and Cohn et al.2 reported an association between chronic pancreatitis and mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Sharer et al. concluded that none of their patients met the diagnostic criteria for cystic fibrosis, whereas Cohn et al. identified one patient as having an "atypical cystic fibrosis phenotype." The diagnostic criteria established by a consensus panel of the Cystic Fibrosis Foundation3 require one or more characteristic phenotypic features and one of three laboratory findings: an elevated sweat chloride concentration on two occasions, the identification . . . [Full Text of this Article]

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