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Correspondence
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Volume 340:321 January 28, 1999 Number 4
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Absence of Toxicity of Avenin in Patients with Dermatitis Herpetiformis

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To the Editor: Several studies have shown that oats are not toxic in patients with celiac disease and dermatitis herpetiformis.1,2,3,4 Avenin is a protein in oats and has similarities to wheat gliadin. Both are prolamins and are rich in glutamine and proline. It has been argued that in large quantities avenin may still be toxic in patients with celiac disease because of the similarity of the peptide sequences in avenin and gliadin. We therefore conducted an avenin-challenge study in two patients with dermatitis herpetiformis and gluten-sensitive enteropathy. The two patients had been following a gluten-free diet for 28 and 26 . . . [Full Text of this Article]

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