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Previous Volume 340:394-395 February 4, 1999 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In 1995 we reported in the Journal the results of a molecular analysis of single Reed–Sternberg cells in biopsy specimens from patients with Hodgkin's disease.¹ Amplified immunoglobulin heavy-chain gene sequences bore the hallmarks of B cells, and in 6 of the 12 cases we studied, there was evidence of the presence of monoclonal Reed–Sternberg cells — that is, identical immunoglobulin-gene rearrangements in several different Reed–Sternberg cells. Unexpectedly, we also found polyclonal Reed–Sternberg cells (i.e., cells with unrelated immunoglobulin-gene rearrangements). Other groups have also found polyclonal Reed–Sternberg cells,² but some investigators indicated that the cells in individual cases . . . [Full Text of this Article]

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