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Previous Volume 340:448-454 February 11, 1999 Number 6 Next

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A large number of changes, distant from the site or sites of inflammation and involving many organ systems, may accompany inflammation. In 1930 interest was focused on these changes by the discovery of C-reactive protein (so named because it reacted with the pneumococcal C-polysaccharide) in the plasma of patients during the acute phase of pneumococcal pneumonia.¹ Accordingly, these systemic changes have since been referred to as the acute-phase response,² even though they accompany both acute and chronic inflammatory disorders. New acute-phase phenomena continue to be recognized, and the mechanisms mediating them are becoming better understood. This review summarizes much of . . . [Full Text of this Article]

Acute-Phase Responses

Regulation of Acute-Phase Changes

Induction of Acute-Phase Proteins by Cytokines and Other Extracellular Signaling Molecules

Regulation of Other Acute-Phase Changes by Inflammation-Associated Cytokines

Postulated Function of the Acute-Phase Response

Clinical Assessment of Acute-Phase Proteins and Cytokines

Conclusions

Source Information

From the Division of Rheumatology, Department of Medicine, University of Colorado Health Sciences Center, Denver (C.G.); and the Departments of Medicine and Pathology and the Rammelkamp Center for Research, Case Western Reserve University, MetroHealth Campus, Cleveland (I.K.).

Address reprint requests to Dr. Kushner at the Department of Medicine, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109-1998, or at ixk2@po.cwru.edu.

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