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Previous Volume 340:517-523 February 18, 1999 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Editorial by Waldvogel, F. A. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Over the past two decades, vancomycin has been considered the antibiotic of choice for methicillin-resistant Staphylococcus aureus (MRSA) infections. Indeed, multidrug-resistant clones of MRSA for which the only available effective antibacterial agent is vancomycin have recently been identified. Recent reports describing the therapeutic failure of vancomycin for MRSA infections have aroused considerable concern regarding the emergence of MRSA strains for which there will be no effective therapy.^1,2,3 The mechanism of reduced susceptibility in these staphylococcal strains has not been identified, although data indicate that it is not the same as the vancomycin-resistance mechanism in enterococcal strains.⁴

We describe here microbiologic . . . [Full Text of this Article]

Case Report

Methods

Testing for Susceptibility to Antimicrobial Agents

Characterization of Vancomycin-Resistant Isolates

Results

Reduced Susceptibility to Vancomycin and Resistance to Other Antibiotics in MRSA Strain PC-3

Genetic Relatedness of MRSA Isolates PC-1, PC-2, and PC-3

Selection of Highly Vancomycin-Resistant S. aureus in Vitro

Genetic Relatedness to Strain PC-3 of an MRSA Clone Widely Spread in Metropolitan New York City

Susceptibility to Vancomycin

Some Properties of the Vancomycin-Resistant Strain PC-3

Effect of Synergistic Combinations of Vancomycin and -Lactam Antibiotics

Discussion

Source Information

From the Laboratory of Microbiology, Rockefeller University, New York (K.S., R.B.R., A.T.); New York Hospital–Cornell Medical Center, New York (R.B.R.); and United Hospital Medical Center, Port Chester, N.Y. (S.W.H.).

Address reprint requests to Dr. Tomasz at the Laboratory of Microbiology, Rockefeller University, 1230 York Ave., New York, NY 10021, or at tomasz@rockvax.rockefeller.edu.

References

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N Engl J Med 1999; 341:1624-1626, Nov 18, 1999. Correspondence

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