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Correspondence
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Volume 340:566-568 February 18, 1999 Number 7
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PC-SPES in Prostate Cancer

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 by DiPaola, R. S.
To the Editor: Although DiPaola et al. (Sept. 17 issue)1 have done a superb job of evaluating the estrogenic properties of PC-SPES, a commercially available combination of eight herbs, there is an implication that this is the only "active" component of this compound. For example, the Results section includes a subsection entitled "Composition of PC-SPES," although this subsection more accurately is a comparative analysis of only the estrogenic components of PC-SPES. Other studies of ethanolic extracts of PC-SPES have identified a large number of components, far more than the four peaks noted by DiPaola et al. on high-performance liquid chromatography.2 . . . [Full Text of this Article]

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