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Previous Volume 340:570 February 18, 1999 Number 7 Next

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To the Editor: Citing a high median lethal dose to suggest that -butyrolactone is not a poison, Gorton (Sept. 17 issue)¹ obscures the unfortunate fact that the doses and the circumstances under which many people are misusing the substance can result in coma or death. The median lethal dose of 4.28 g per kilogram of body weight places -butyrolactone in the "moderately toxic" category,² along with other chemicals such as rubbing alcohol and antifreeze. Does Gorton want to suggest that these are not "poisons"?

It is difficult to understand Gorton's attempt to differentiate "coma" from "deep sleep." If users pass . . . [Full Text of this Article]

References

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Extract | Full Text  
N Engl J Med 1998; 339:848-849, Sep 17, 1998. Correspondence

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