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Previous Volume 340:709-718 March 4, 1999 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Fertility in women is regulated by a series of highly coordinated and synchronized interactions in the hypothalamic–pituitary–ovarian axis (Figure 1A). The central regulator of the axis is the group of neurons that secrete gonadotropin-releasing hormone (GnRH).¹ Their cell bodies reside in the arcuate nucleus, and their exons terminate in the median eminence near the hypothalamic–pituitary portal vasculature. These neurons are unique in that they have an intrinsic firing frequency such that GnRH is secreted in pulses at 60-to-90-minute intervals into the portal vasculature to be conveyed to the anterior pituitary gland. There GnRH binds to specific cell-surface receptors . . . [Full Text of this Article]

Kallmann's Syndrome

Resistance to Gonadotropin-Releasing Hormone

Isolated Deficiency of Follicle-Stimulating Hormone

Hypergonadotropic Hypogonadism

Resistance to Luteinizing Hormone

Congenital Lipoid Adrenal Hyperplasia

Galactosemia

McCune–Albright Syndrome

Aromatase Deficiency

Congenital Adrenal Hyperplasia Caused by Deficiency of 3ß-Hydroxysteroid Dehydrogenase Type II

Congenital Adrenal Hyperplasia Caused by 17-Hydroxylase and 17,20-Lyase Deficiency

Conclusions

Source Information

From the Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City.

Address reprint requests to Dr. Adashi at the Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, 546 Chipeta Way, Rm. 109, Salt Lake City, UT 84108, or at eadashi@hsc.utah.edu.

References

This article has been cited by other articles:

• Toyama, R., Fujimori, T., Nabeshima, Y., Itoh, Y., Tsuji, Y., Osamura, R. Y., Nabeshima, Y.-I. (2006). Impaired Regulation of Gonadotropins Leads to the Atrophy of the Female Reproductive System in klotho-Deficient Mice. Endocrinology 147: 120-129 [Abstract] [Full Text]  
• Zhao, L, Bakke, M, Krimkevich, Y, Cushman, L., Parlow, A., Camper, S., Parker, K. (2001). Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development 128: 147-154 [Abstract]  
• Rosene-Montella, K., Keely, E., Laifer, S. A., Lee, R. V. (2000). Evaluation and Management of Infertility in Women: The Internists' Role. ANN INTERN MED 132: 973-981 [Abstract] [Full Text]  
• Qin, K.-n., Rosenfield, R. L. (2000). Expression of 17{beta}-Hydroxysteroid Dehydrogenase Type 5 in Human Ovary: A Pilot Study. Reproductive Sciences 7: 61-64 [Abstract]