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Previous Volume 340:737-738 March 4, 1999 Number 9 Next

/ T-Cell Stimulation by Pamidronate

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To the Editor: Bisphosphonates are widely used to inhibit osteoclastic bone resorption. As analogues of pyrophosphate they share several structural homologies with recently identified non-peptide / T-cell ligands, such as isopentenyl pyrophosphate, that activate antigenic receptors of / T cells.¹

We recently found that aminobisphosphonates (pamidronate, ibandronate, and alendronate) can stimulate the major subgroup of / T cells in peripheral blood (V9V2+ T cells), whereas non-aminobisphosphonates (clodronate and etidronate) are inactive. In our assays, pamidronate (concentration yielding half-maximal activity, 5 to 10 µM) induced the activation and selective expansion of / T cells in cultures of peripheral-blood mononuclear . . . [Full Text of this Article]

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