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Previous Volume 341:733-736 September 2, 1999 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Editorial by Le Roith, D. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Hypoglycemia is a condition commonly seen in the emergency department and is usually caused by insulin or sulfonylurea therapy for diabetes mellitus. Tumor-induced hypoglycemia occurs more rarely and can involve several mechanisms, according to whether the tumor is of pancreatic islet-cell origin or of extrapancreatic, non–islet-cell origin.¹ The pancreatic islet beta-cell tumors (insulinomas) cause hypoglycemia by producing excessive insulin. In contrast, non–islet-cell tumors can cause hypoglycemia in any of several ways. They include release by the tumor of insulin-like growth factor II or its high-molecular-weight precursor,^2,3,4 multiple metastases to the liver, massive tumor burden, or rarely, the production of autoantibodies . . . [Full Text of this Article]

Case Report

Methods

Hormone Assays

Immunohistochemical Studies

In Situ Hybridization

Discussion

Source Information

From the Departments of Cancer Medicine (M.J.S., P.J.M.), Histochemistry (A.E.B.), and Radiotherapy (M.G.), Imperial College School of Medicine, Charing Cross and Hammersmith Campus, London; the Supraregional Assay Service Peptide Centre, Clinical Laboratory, Royal Surrey County Hospital, Guildford (J.D.T.); the Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge University, Cambridge (C.N.H.); the Department of Oncology, North Herts National Health Service Trust, Stevenage (S.W.); and the Molecular Medicine Centre, Edinburgh University, Western General Hospital, Edinburgh (J.R.S.) — all in the United Kingdom.

Address reprint requests to Dr. Michael J. Seckl at the Department of Cancer Medicine, Charing Cross Hospital, Fulham Palace Rd., London W6 8RF, United Kingdom, or at m.seckl@ic.ac.uk.

References

This article has been cited by other articles:

• Nauck, M. A., Reinecke, M., Perren, A., Frystyk, J., Berishvili, G., Zwimpfer, C., Figge, A. M., Flyvbjerg, A., Lankisch, P. G., Blum, W. F., Kloppel, G., Schmiegel, W., Zapf, J. (2007). Hypoglycemia due to Paraneoplastic Secretion of Insulin-Like Growth Factor-I in a Patient with Metastasizing Large-Cell Carcinoma of the Lung. J. Clin. Endocrinol. Metab. 92: 1600-1605 [Abstract] [Full Text]  
• Cunha, D. A., Carneiro, E. M., Alves, M. d. C., Jorge, A. G., de Sousa, S. M., Boschero, A. C., Saad, M. J. A., Velloso, L. A., Rocha, E. M. (2005). Insulin secretion by rat lachrymal glands: effects of systemic and local variables. Am. J. Physiol. Endocrinol. Metab. 289: E768-E775 [Abstract] [Full Text]  
• Kaltsas, G. A., Besser, G. M., Grossman, A. B. (2004). The Diagnosis and Medical Management of Advanced Neuroendocrine Tumors. Endocr. Rev. 25: 458-511 [Abstract] [Full Text]  
• Teale, J D, Wark, G, Marks, V (2002). The biochemical investigation of cases of hypoglycaemia: an assessment of the clinical effectiveness of analytical services. J. Clin. Pathol. 55: 503-507 [Abstract] [Full Text]  
• Rocha, E. M., Cunha, D. A., Carneiro, E. M., Boschero, A. C., Saad, M. J. A., Velloso, L. A. (2002). Identification of Insulin in the Tear Film and Insulin Receptor and IGF-I Receptor on the Human Ocular Surface. IOVS 43: 963-967 [Abstract] [Full Text]  
• Furrer, J., Hättenschwiler, A., Komminoth, P., Pfammatter, T., Wiesli, P. (2001). Carcinoid Syndrome, Acromegaly, and Hypoglycemia Due to an Insulin-Secreting Neuroendocrine Tumor of the Liver. J. Clin. Endocrinol. Metab. 86: 2227-2230 [Abstract] [Full Text]  
• Le Roith, D. (1999). Tumor-Induced Hypoglycemia. NEJM 341: 757-758 [Full Text]