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Previous Volume 341:738-746 September 2, 1999 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The primary function of the skin is to serve as a protective barrier against the environment. Loss of the integrity of large portions of the skin as a result of injury or illness may lead to major disability or even death. Every year in the United States more than 1.25 million people have burns¹ and 6.5 million have chronic skin ulcers caused by pressure, venous stasis, or diabetes mellitus.²

The primary goals of the treatment of wounds are rapid wound closure and a functional and aesthetically satisfactory scar. Recent advances in cellular and molecular biology have greatly expanded our understanding . . . [Full Text of this Article]

Biology of Wound Healing

Inflammation

Epithelialization

Formation of Granulation Tissue

Neovascularization

Wound Contraction and Extracellular-Matrix Reorganization

Abnormal Wound Healing

Clinical Experience with Growth Factors

Insights from Fetal Wound Healing

Skin Substitutes

Epidermal Skin Substitutes

Dermal Skin Substitutes

Combined Dermal and Epidermal Skin Substitutes

Clinical Implications

Source Information

From the Departments of Emergency Medicine (A.J.S.) and Dermatology (R.A.F.C.), State University of New York at Stony Brook, Stony Brook.

Address reprint requests to Dr. Singer at the Department of Emergency Medicine, University Medical Center, State University of New York at Stony Brook, Stony Brook, NY 11794-8350.

References

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• Meng, F., Cheng, X., Yang, L., Hou, N., Yang, X., Meng, A. (2008). Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGF{beta} signaling. J. Cell Sci. 121: 2904-2912 [Abstract] [Full Text]  
• Nanney, L. B., Woodrell, C. D., Greives, M. R., Cardwell, N. L., Pollins, A. C., Bancroft, T. A., Chesser, A., Michalak, M., Rahman, M., Siebert, J. W., Gold, L. I. (2008). Calreticulin Enhances Porcine Wound Repair by Diverse Biological Effects. Am. J. Pathol. 173: 610-630 [Abstract] [Full Text]  
• Hull, M. L., Escareno, C. R., Godsland, J. M., Doig, J. R., Johnson, C. M., Phillips, S. C., Smith, S. K., Tavare, S., Print, C. G., Charnock-Jones, D. S. (2008). Endometrial-Peritoneal Interactions during Endometriotic Lesion Establishment. Am. J. Pathol. 173: 700-715 [Abstract] [Full Text]  
• Lam, C.-F., Chang, P.-J., Huang, Y.-S., Sung, Y.-H., Huang, C.-C., Lin, M.-W., Liu, Y.-C., Tsai, Y.-C. (2008). Prolonged Use of High-Dose Morphine Impairs Angiogenesis and Mobilization of Endothelial Progenitor Cells in Mice. Anesth. Analg. 107: 686-692 [Abstract] [Full Text]  
• Usui, M. L., Mansbridge, J. N., Carter, W. G., Fujita, M., Olerud, J. E. (2008). Keratinocyte Migration, Proliferation, and Differentiation in Chronic Ulcers From Patients With Diabetes and Normal Wounds. J. Histochem. Cytochem. 56: 687-696 [Abstract] [Full Text]  
• El-Okdi, N., Smaili, S., Raju, V., Shidyak, A., Gupta, S., Fedorova, L., Elkareh, J., Periyasamy, S., Shapiro, A. P., Kahaleh, M. B., Malhotra, D., Xie, Z., Chin, K. V., Shapiro, J. I. (2008). Effects of cardiotonic steroids on dermal collagen synthesis and wound healing. J. Appl. Physiol. 105: 30-36 [Abstract] [Full Text]  
• Otteson, T. D., Sandulache, V. C., Barsic, M., DiSilvio, G. M., Hebda, P. A., Dohar, J. E. (2008). Acute and Chronic Changes in the Subglottis Induced by Graded Carbon Dioxide Laser Injury in the Rabbit Airway. Arch Otolaryngol Head Neck Surg 134: 694-702 [Abstract] [Full Text]  
• Radek, K. A., Kovacs, E. J., Gallo, R. L., DiPietro, L. A. (2008). Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 295: H174-H184 [Abstract] [Full Text]  
• Reitzel, A. M., Sullivan, J. C., Traylor-knowles, N., Finnerty, J. R. (2008). Genomic Survey of Candidate Stress-Response Genes in the Estuarine Anemone Nematostella vectensis. Biol. Bull. 214: 233-254 [Abstract] [Full Text]  
• Schiefelbein, D., Goren, I., Fisslthaler, B., Schmidt, H., Geisslinger, G., Pfeilschifter, J., Frank, S. (2008). Biphasic Regulation of HMG-CoA Reductase Expression and Activity during Wound Healing and Its Functional Role in the Control of Keratinocyte Angiogenic and Proliferative Responses. J. Biol. Chem. 283: 15479-15490 [Abstract] [Full Text]  
• Cheng, C.-F., Fan, J., Fedesco, M., Guan, S., Li, Y., Bandyopadhyay, B., Bright, A. M., Yerushalmi, D., Liang, M., Chen, M., Han, Y.-P., Woodley, D. T., Li, W. (2008). Transforming Growth Factor {alpha} (TGF{alpha})-Stimulated Secretion of HSP90{alpha}: Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGF{beta}-Rich Environment during Wound Healing. Mol. Cell. Biol. 28: 3344-3358 [Abstract] [Full Text]  
• Radek, K. A., Baer, L. A., Eckhardt, J., DiPietro, L. A., Wade, C. E. (2008). Mechanical unloading impairs keratinocyte migration and angiogenesis during cutaneous wound healing. J. Appl. Physiol. 104: 1295-1303 [Abstract] [Full Text]  
• Yu, B. D., Mukhopadhyay, A., Wong, C. (2008). Skin and hair: models for exploring organ regeneration. Hum Mol Genet 17: R54-R59 [Abstract] [Full Text]  
• Hollinger, J. O., Hart, C. E., Hirsch, S. N., Lynch, S., Friedlaender, G. E. (2008). Recombinant Human Platelet-Derived Growth Factor: Biology and Clinical Applications. JBJS 90: 48-54 [Abstract] [Full Text]  
• Liu, S., Wang, H., Currie, B. M., Molinolo, A., Leung, H. J., Moayeri, M., Basile, J. R., Alfano, R. W., Gutkind, J. S., Frankel, A. E., Bugge, T. H., Leppla, S. H. (2008). Matrix Metalloproteinase-activated Anthrax Lethal Toxin Demonstrates High Potency in Targeting Tumor Vasculature. J. Biol. Chem. 283: 529-540 [Abstract] [Full Text]  
• Sloan, J (2008). Soft tissue injuries: introduction and basic principles. Emerg. Med. J. 25: 33-37 [Abstract] [Full Text]  
• Horowitz, J. C., Rogers, D. S., Simon, R. H., Sisson, T. H., Thannickal, V. J. (2008). Plasminogen Activation Induced Pericellular Fibronectin Proteolysis Promotes Fibroblast Apoptosis. Am. J. Respir. Cell Mol. Bio. 38: 78-87 [Abstract] [Full Text]  
• Ishida, Y., Gao, J.-L., Murphy, P. M. (2008). Chemokine Receptor CX3CR1 Mediates Skin Wound Healing by Promoting Macrophage and Fibroblast Accumulation and Function. J. Immunol. 180: 569-579 [Abstract] [Full Text]  
• Phillippi, J. A., Miller, E., Weiss, L., Huard, J., Waggoner, A., Campbell, P. (2008). Microenvironments Engineered by Inkjet Bioprinting Spatially Direct Adult Stem Cells Toward Muscle- and Bone-Like Subpopulations. Stem Cells 26: 127-134 [Abstract] [Full Text]  
• Cardoso, J. F., Souza, B. R., Amadeu, T. P., Valenca, S. S., Porto, L. C. M. S., Costa, A. M. A. (2007). Effects of Cigarette Smoke in Mice Wound Healing is Strain Dependent. Toxicol Pathol 35: 890-896 [Abstract] [Full Text]  
• Taboubi, S., Milanini, J., Delamarre, E., Parat, F., Garrouste, F., Pommier, G., Takasaki, J., Hubaud, J.-C., Kovacic, H., Lehmann, M. (2007). G{alpha}(q/11)-coupled P2Y2 nucleotide receptor inhibits human keratinocyte spreading and migration. FASEB J. 21: 4047-4058 [Abstract] [Full Text]  
• Braiman-Wiksman, L., Solomonik, I., Spira, R., Tennenbaum, T. (2007). Novel Insights into Wound Healing Sequence of Events. Toxicol Pathol 35: 767-779 [Abstract] [Full Text]  
• Vaneau, M., Chaby, G., Guillot, B., Martel, P., Senet, P., Teot, L., Chosidow, O. (2007). Consensus Panel Recommendations for Chronic and Acute Wound Dressings. Arch Dermatol 143: 1291-1294 [Abstract] [Full Text]  
• Chaby, G., Senet, P., Vaneau, M., Martel, P., Guillaume, J.-C., Meaume, S., Teot, L., Debure, C., Dompmartin, A., Bachelet, H., Carsin, H., Matz, V., Richard, J. L., Rochet, J. M., Sales-Aussias, N., Zagnoli, A., Denis, C., Guillot, B., Chosidow, O. (2007). Dressings for Acute and Chronic Wounds: A Systematic Review. Arch Dermatol 143: 1297-1304 [Abstract] [Full Text]  
• Aarabi, S., Bhatt, K. A., Shi, Y., Paterno, J., Chang, E. I., Loh, S. A., Holmes, J. W., Longaker, M. T., Yee, H., Gurtner, G. C. (2007). Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J. 21: 3250-3261 [Abstract] [Full Text]  
• Wu, Y., Chen, L., Scott, P. G., Tredget, E. E. (2007). Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis. Stem Cells 25: 2648-2659 [Abstract] [Full Text]  
• Yukami, T., Hasegawa, M., Matsushita, Y., Fujita, T., Matsushita, T., Horikawa, M., Komura, K., Yanaba, K., Hamaguchi, Y., Nagaoka, T., Ogawa, F., Fujimoto, M., Steeber, D. A., Tedder, T. F., Takehara, K., Sato, S. (2007). Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. J. Leukoc. Biol. 82: 519-531 [Abstract] [Full Text]  
• Gutierrez-Fernandez, A., Inada, M., Balbin, M., Fueyo, A., Pitiot, A. S., Astudillo, A., Hirose, K., Hirata, M., Shapiro, S. D., Noel, A., Werb, Z., Krane, S. M., Lopez-Otin, C., Puente, X. S. (2007). Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J. 21: 2580-2591 [Abstract] [Full Text]  
• Kwon, A-H., Qiu, Z., Hirao, Y. (2007). Topical Application of Plasma Fibronectin in Full-Thickness Skin Wound Healing in Rats. Exp. Biol. Med. 232: 935-941 [Abstract] [Full Text]  
• Deiner, C., Shagdarsuren, E., Schwimmbeck, P. L., Rosenthal, P., Loddenkemper, C., Rauch, U., Pauschinger, M., Dietz, R., Schultheiss, H.-P., Dechend, R., Pels, K. (2007). Nf-{kappa}b and AP-1 activation is associated with late lumen loss after porcine coronary angioplasty and antiproliferative beta-irradiation. Cardiovasc Res 75: 195-204 [Abstract] [Full Text]  
• Agren, M. S., Werthen, M. (2007). The Extracellular Matrix in Wound Healing: A Closer Look at Therapeutics for Chronic Wounds. INT J LOW EXTREM WOUNDS 6: 82-97 [Abstract]  
• Grande-Garcia, A., Echarri, A., de Rooij, J., Alderson, N. B., Waterman-Storer, C. M., Valdivielso, J. M., del Pozo, M. A. (2007). Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases. J. Cell Biol. 177: 683-694 [Abstract] [Full Text]  
• Roos, N., Poulalhon, N., Farge, D., Madelaine, I., Mauviel, A., Verrecchia, F. (2007). In Vitro Evidence for a Direct Antifibrotic Role of the Immunosuppressive Drug Mycophenolate Mofetil. J. Pharmacol. Exp. Ther. 321: 583-589 [Abstract] [Full Text]  
• Chmielowiec, J., Borowiak, M., Morkel, M., Stradal, T., Munz, B., Werner, S., Wehland, J., Birchmeier, C., Birchmeier, W. (2007). c-Met is essential for wound healing in the skin. J. Cell Biol. 177: 151-162 [Abstract] [Full Text]  
• Blikslager, A. T., Moeser, A. J., Gookin, J. L., Jones, S. L., Odle, J. (2007). Restoration of Barrier Function in Injured Intestinal Mucosa. Physiol. Rev. 87: 545-564 [Abstract] [Full Text]  
• Sandulache, V. C., Chafin, J. B., Li-Korotky, H.-S., Otteson, T. D., Dohar, J. E., Hebda, P. A. (2007). Elucidating the Role of Interleukin 1beta and Prostaglandin E2 in Upper Airway Mucosal Wound Healing. Arch Otolaryngol Head Neck Surg 133: 365-374 [Abstract] [Full Text]  
• Maruyama, K., Asai, J., Ii, M., Thorne, T., Losordo, D. W., D'Amore, P. A. (2007). Decreased Macrophage Number and Activation Lead to Reduced Lymphatic Vessel Formation and Contribute to Impaired Diabetic Wound Healing. Am. J. Pathol. 170: 1178-1191 [Abstract] [Full Text]  
• Papanas, N., Maltezos, E. (2007). Growth Factors in the Treatment of Diabetic Foot Ulcers: New Technologies, Any Promises?. INT J LOW EXTREM WOUNDS 6: 37-53 [Abstract]  
• LaGier, A. J., Yoo, S. H., Alfonso, E. C., Meiners, S., Fini, M. E. (2007). Inhibition of Human Corneal Epithelial Production of Fibrotic Mediator TGF-{beta}2 by Basement Membrane-Like Extracellular Matrix. IOVS 48: 1061-1071 [Abstract] [Full Text]  
• Zheng, Y., Watanabe, M., Kuraishi, T., Hattori, S., Kai, C., Shibuya, M. (2007). Chimeric VEGF-ENZ7/PlGF Specifically Binding to VEGFR-2 Accelerates Skin Wound Healing via Enhancement of Neovascularization. Arterioscler. Thromb. Vasc. Bio. 27: 503-511 [Abstract] [Full Text]  
• Sa, S. M., Valdez, P. A., Wu, J., Jung, K., Zhong, F., Hall, L., Kasman, I., Winer, J., Modrusan, Z., Danilenko, D. M., Ouyang, W. (2007). The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis. J. Immunol. 178: 2229-2240 [Abstract] [Full Text]  
• Himes, K. P., Simhan, H. N. (2007). Time From Cervical Conization to Pregnancy and Preterm Birth. Obstet Gynecol 109: 314-319 [Abstract] [Full Text]  
• Mathieu, D. (2006). Role of hyperbaric oxygen therapy in the management of lower extremity wounds.. INT J LOW EXTREM WOUNDS 5: 233-235  
• Zhang, Y., Taveggia, C., Melendez-Vasquez, C., Einheber, S., Raine, C. S., Salzer, J. L., Brosnan, C. F., John, G. R. (2006). Interleukin-11 Potentiates Oligodendrocyte Survival and Maturation, and Myelin Formation.. J. Neurosci. 26: 12174-12185 [Abstract] [Full Text]  
• Giacco, F., Perruolo, G., D'Agostino, E., Fratellanza, G., Perna, E., Misso, S., Saldalamacchia, G., Oriente, F., Fiory, F., Miele, C., Formisano, S., Beguinot, F., Formisano, P. (2006). Thrombin-activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin-like growth factor-1. FASEB J. 20: 2402-2404 [Abstract] [Full Text]  
• Li, L., Heldin, C.-H., Heldin, P. (2006). Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44. J. Biol. Chem. 281: 26512-26519 [Abstract] [Full Text]  
• Cordier, J-F. (2006). Cryptogenic organising pneumonia.. Eur Respir J 28: 422-446 [Abstract] [Full Text]  
• Pullar, C. E., Rizzo, A., Isseroff, R. R. (2006). beta-Adrenergic Receptor Antagonists Accelerate Skin Wound Healing: EVIDENCE FOR A CATECHOLAMINE SYNTHESIS NETWORK IN THE EPIDERMIS. J. Biol. Chem. 281: 21225-21235 [Abstract] [Full Text]  
• Pilling, D., Tucker, N. M., Gomer, R. H. (2006). Aggregated IgG inhibits the differentiation of human fibrocytes. J. Leukoc. Biol. 79: 1242-1251 [Abstract] [Full Text]  
• Asai, J., Takenaka, H., Kusano, K. F., Ii, M., Luedemann, C., Curry, C., Eaton, E., Iwakura, A., Tsutsumi, Y., Hamada, H., Kishimoto, S., Thorne, T., Kishore, R., Losordo, D. W. (2006). Topical Sonic Hedgehog Gene Therapy Accelerates Wound Healing in Diabetes by Enhancing Endothelial Progenitor Cell-Mediated Microvascular Remodeling. Circulation 113: 2413-2424 [Abstract] [Full Text]  
• Yahata, Y., Shirakata, Y., Tokumaru, S., Yang, L., Dai, X., Tohyama, M., Tsuda, T., Sayama, K., Iwai, M., Horiuchi, M., Hashimoto, K. (2006). A Novel Function of Angiotensin II in Skin Wound Healing: INDUCTION OF FIBROBLAST AND KERATINOCYTE MIGRATION BY ANGIOTENSIN II VIA HEPARIN-BINDING EPIDERMAL GROWTH FACTOR (EGF)-LIKE GROWTH FACTOR-MEDIATED EGF RECEPTOR TRANSACTIVATION. J. Biol. Chem. 281: 13209-13216 [Abstract] [Full Text]  
• Ishida, Y., Kondo, T., Kimura, A., Matsushima, K., Mukaida, N. (2006). Absence of IL-1 Receptor Antagonist Impaired Wound Healing along with Aberrant NF-{kappa}B Activation and a Reciprocal Suppression of TGF-beta Signal Pathway. J. Immunol. 176: 5598-5606 [Abstract] [Full Text]  
• Enoch, S., Grey, J. E, Harding, K. G (2006). Recent advances and emerging treatments. BMJ 332: 962-965 [Full Text]  
• Meyer-ter-Vehn, T., Gebhardt, S., Sebald, W., Buttmann, M., Grehn, F., Schlunck, G., Knaus, P. (2006). p38 Inhibitors Prevent TGF-{beta}-Induced Myofibroblast Transdifferentiation in Human Tenon Fibroblasts.. IOVS 47: 1500-1509 [Abstract] [Full Text]  
• Cheon, S. S., Wei, Q., Gurung, A., Youn, A., Bright, T., Poon, R., Whetstone, H., Guha, A., Alman, B. A. (2006). Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J. 20: 692-701 [Abstract] [Full Text]  
• Zarbin, M A (2006). Progressive RPE atrophy around disciform scars.. Br. J. Ophthalmol. 90: 396-397 [Full Text]  
• Haugh, J. M. (2006). Deterministic Model of Dermal Wound Invasion Incorporating Receptor-Mediated Signal Transduction and Spatial Gradient Sensing. Biophys. J 90: 2297-2308 [Abstract] [Full Text]  
• Athanasopoulos, A. N., Economopoulou, M., Orlova, V. V., Sobke, A., Schneider, D., Weber, H., Augustin, H. G., Eming, S. A., Schubert, U., Linn, T., Nawroth, P. P., Hussain, M., Hammes, H.-P., Herrmann, M., Preissner, K. T., Chavakis, T. (2006). The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms. Blood 107: 2720-2727 [Abstract] [Full Text]  
• Bandyopadhyay, B., Fan, J., Guan, S., Li, Y., Chen, M., Woodley, D. T., Li, W. (2006). A "traffic control" role for TGF{beta}3: orchestrating dermal and epidermal cell motility during wound healing. J. Cell Biol. 172: 1093-1105 [Abstract] [Full Text]  
• Sweitzer, S. M., Fann, S. A., Borg, T. K., Baynes, J. W., Yost, M. J. (2006). What is the future of diabetic wound care?. The Diabetes Educator 32: 197-210 [Abstract] [Full Text]  
• Park, K.-S., Wells, J. M., Zorn, A. M., Wert, S. E., Laubach, V. E., Fernandez, L. G., Whitsett, J. A. (2006). Transdifferentiation of Ciliated Cells during Repair of the Respiratory Epithelium. Am. J. Respir. Cell Mol. Bio. 34: 151-157 [Abstract] [Full Text]  
• Pullar, C. E., Grahn, J. C., Liu, W., Isseroff, R. R. (2006). {beta}2-Adrenergic receptor activation delays wound healing. FASEB J. 20: 76-86 [Abstract] [Full Text]  
• Godbout, C., Frenette, J. (2006). Periodic Direct Current Does Not Promote Wound Closure in an In Vitro Dynamic Model of Cell Migration. ptjournal 86: 50-59 [Abstract] [Full Text]  
• Schneider, I. C., Haugh, J. M. (2005). Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts. J. Cell Biol. 171: 883-892 [Abstract] [Full Text]  
• Sandulache, V. C., Dohar, J. E., Hebda, P. A. (2005). Fibroblast Transplantation in the Airway: Implications for Subglottic Stenosis. Arch Otolaryngol Head Neck Surg 131: 1090-1096 [Abstract] [Full Text]  
• Wesselkamper, S. C., Case, L. M., Henning, L. N., Borchers, M. T., Tichelaar, J. W., Mason, J. M., Dragin, N., Medvedovic, M., Sartor, M. A., Tomlinson, C. R., Leikauf, G. D. (2005). Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor {beta}. Am. J. Respir. Crit. Care Med. 172: 1399-1411 [Abstract] [Full Text]  
• Brasselet, C., Durand, E., Addad, F., Zen, A. A. H., Smeets, M. B., Laurent-Maquin, D., Bouthors, S., Bellon, G., de Kleijn, D., Godeau, G., Garnotel, R., Gogly, B., Lafont, A. (2005). Collagen and elastin cross-linking: a mechanism of constrictive remodeling after arterial injury. Am. J. Physiol. Heart Circ. Physiol. 289: H2228-H2233 [Abstract] [Full Text]  
• Suh, W., Kim, K. L., Kim, J.-M., Shin, I.-S., Lee, Y.-S., Lee, J.-Y., Jang, H.-S., Lee, J.-S., Byun, J., Choi, J.-H., Jeon, E.-S., Kim, D.-K. (2005). Transplantation of Endothelial Progenitor Cells Accelerates Dermal Wound Healing with Increased Recruitment of Monocytes/Macrophages and Neovascularization. Stem Cells 23: 1571-1578 [Abstract] [Full Text]  
• Riboldi, E., Musso, T., Moroni, E., Urbinati, C., Bernasconi, S., Rusnati, M., Adorini, L., Presta, M., Sozzani, S. (2005). Cutting Edge: Proangiogenic Properties of Alternatively Activated Dendritic Cells. J. Immunol. 175: 2788-2792 [Abstract] [Full Text]  
• Nelson, C. M., Jean, R. P., Tan, J. L., Liu, W. F., Sniadecki, N. J., Spector, A. A., Chen, C. S. (2005). From the Cover: Emergent patterns of growth controlled by multicellular form and mechanics. Proc. Natl. Acad. Sci. USA 102: 11594-11599 [Abstract] [Full Text]  
• Komi-Kuramochi, A., Kawano, M., Oda, Y., Asada, M., Suzuki, M., Oki, J., Imamura, T. (2005). Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice. J Endocrinol 186: 273-289 [Abstract] [Full Text]  
• Sista, A. K., O'Connell, M. K., Hinohara, T., Oommen, S. S., Fenster, B. E., Glassford, A. J., Schwartz, E. A., Taylor, C. A., Reaven, G. M., Tsao, P. S. (2005). Increased aortic stiffness in the insulin-resistant Zucker fa/fa rat. Am. J. Physiol. Heart Circ. Physiol. 289: H845-H851 [Abstract] [Full Text]  
• Deehan, D. J., Cawston, T. E. (2005). The biology of integration of the anterior cruciate ligament. J Bone Joint Surg Br 87-B: 889-895 [Full Text]  
• Lyu, J., Joo, C.-K. (2005). Wnt-7a Up-regulates Matrix Metalloproteinase-12 Expression and Promotes Cell Proliferation in Corneal Epithelial Cells during Wound Healing. J. Biol. Chem. 280: 21653-21660 [Abstract] [Full Text]  
• Shirakata, Y., Kimura, R., Nanba, D., Iwamoto, R., Tokumaru, S., Morimoto, C., Yokota, K., Nakamura, M., Sayama, K., Mekada, E., Higashiyama, S., Hashimoto, K. (2005). Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing. J. Cell Sci. 118: 2363-2370 [Abstract] [Full Text]  
• Faucherre, A., Desbois, P., Nagano, F., Satre, V., Lunardi, J., Gacon, G., Dorseuil, O. (2005). Lowe syndrome protein Ocrl1 is translocated to membrane ruffles upon Rac GTPase activation: a new perspective on Lowe syndrome pathophysiology. Hum Mol Genet 14: 1441-1448 [Abstract] [Full Text]  
• Miller, L. S., Sorensen, O. E., Liu, P. T., Jalian, H. R., Eshtiaghpour, D., Behmanesh, B. E., Chung, W., Starner, T. D., Kim, J., Sieling, P. A., Ganz, T., Modlin, R. L. (2005). TGF-{alpha} Regulates TLR Expression and Function on Epidermal Keratinocytes. J. Immunol. 174: 6137-6143 [Abstract] [Full Text]  
• Kampfer, H., Schmidt, R., Geisslinger, G., Pfeilschifter, J., Frank, S. (2005). Wound Inflammation in Diabetic ob/ob Mice: Functional Coupling of Prostaglandin Biosynthesis to Cyclooxygenase-1 Activity in Diabetes-Impaired Wound Healing. Diabetes 54: 1543-1551 [Abstract] [Full Text]  
• Florin, L., Maas-Szabowski, N., Werner, S., Szabowski, A., Angel, P. (2005). Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts. J. Cell Sci. 118: 1981-1989 [Abstract] [Full Text]  
• Gronert, K., Maheshwari, N., Khan, N., Hassan, I. R., Dunn, M., Laniado Schwartzman, M. (2005). A Role for the Mouse 12/15-Lipoxygenase Pathway in Promoting Epithelial Wound Healing and Host Defense. J. Biol. Chem. 280: 15267-15278 [Abstract] [Full Text]  
• Pu, J., Zhao, M. (2005). Golgi polarization in a strong electric field. J. Cell Sci. 118: 1117-1128 [Abstract] [Full Text]  
• Gao, Z., Sasaoka, T., Fujimori, T., Oya, T., Ishii, Y., Sabit, H., Kawaguchi, M., Kurotaki, Y., Naito, M., Wada, T., Ishizawa, S., Kobayashi, M., Nabeshima, Y.-I., Sasahara, M. (2005). Deletion of the PDGFR-{beta} Gene Affects Key Fibroblast Functions Important for Wound Healing. J. Biol. Chem. 280: 9375-9389 [Abstract] [Full Text]  
• Satish, L., Blair, H. C., Glading, A., Wells, A. (2005). Interferon-Inducible Protein 9 (CXCL11)-Induced Cell Motility in Keratinocytes Requires Calcium Flux-Dependent Activation of {micro}-Calpain. Mol. Cell. Biol. 25: 1922-1941 [Abstract] [Full Text]  
• Smith, R. G. (2005). A Critical Discussion of the Use of Antiseptics in Acute Traumatic Wounds. J. Am. Podiatr. Med. Assoc. 95: 148-153 [Abstract] [Full Text]  
• Stechmiller, J. K., Childress, B., Cowan, L. (2005). Arginine Supplementation and Wound Healing. Nutr Clin Pract 20: 52-61 [Abstract] [Full Text]  
• Lobmann, R., Schultz, G., Lehnert, H. (2005). Proteases and the Diabetic Foot Syndrome: Mechanisms and Therapeutic Implications. Diabetes Care 28: 461-471 [Full Text]  
• Vittal, R., Horowitz, J. C., Moore, B. B., Zhang, H., Martinez, F. J., Toews, G. B., Standiford, T. J., Thannickal, V. J. (2005). Modulation of Prosurvival Signaling in Fibroblasts by a Protein Kinase Inhibitor Protects against Fibrotic Tissue Injury. Am. J. Pathol. 166: 367-375 [Abstract] [Full Text]  
• Park, S. G., Shin, H., Shin, Y. K., Lee, Y., Choi, E.-C., Park, B.-J., Kim, S. (2005). The Novel Cytokine p43 Stimulates Dermal Fibroblast Proliferation and Wound Repair. Am. J. Pathol. 166: 387-398 [Abstract] [Full Text]  
• Esson, D. W., Popp, M. P., Liu, L., Schultz, G. S., Sherwood, M. B. (2004). Microarray Analysis of the Failure of Filtering Blebs in a Rat Model of Glaucoma Filtering Surgery. IOVS 45: 4450-4462 [Abstract] [Full Text]  
• Kyriakides, T. R., Foster, M. J., Keeney, G. E., Tsai, A., Giachelli, C. M., Clark-Lewis, I., Rollins, B. J., Bornstein, P. (2004). The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation. Am. J. Pathol. 165: 2157-2166 [Abstract] [Full Text]  
• Zhang, X.-j., Chinkes, D. L., Wolfe, R. R. (2004). Leucine Supplementation Has an Anabolic Effect on Proteins in Rabbit Skin Wound and Muscle. J. Nutr. 134: 3313-3318 [Abstract] [Full Text]  
• Kawakami, R., Saito, Y., Kishimoto, I., Harada, M., Kuwahara, K., Takahashi, N., Nakagawa, Y., Nakanishi, M., Tanimoto, K., Usami, S., Yasuno, S., Kinoshita, H., Chusho, H., Tamura, N., Ogawa, Y., Nakao, K. (2004). Overexpression of Brain Natriuretic Peptide Facilitates Neutrophil Infiltration and Cardiac Matrix Metalloproteinase-9 Expression After Acute Myocardial Infarction. Circulation 110: 3306-3312 [Abstract] [Full Text]  
• Brest, P., Turchi, L., Le'Negrate, G., Berto, F., Moreilhon, C., Mari, B., Ponzio, G., Hofman, P. (2004). Escherichia coli Cytotoxic Necrotizing Factor 1 Inhibits Intestinal Epithelial Wound Healing In Vitro after Mechanical Injury. Infect. Immun. 72: 5733-5740 [Abstract] [Full Text]  
• Maytin, E. V., Chung, H. H., Seetharaman, V. M. (2004). Hyaluronan Participates in the Epidermal Response to Disruption of the Permeability Barrier in Vivo. Am. J. Pathol. 165: 1331-1341 [Abstract] [Full Text]  
• Velardo, M. J., Burger, C., Williams, P. R., Baker, H. V., Lopez, M. C., Mareci, T. H., White, T. E., Muzyczka, N., Reier, P. J. (2004). Patterns of Gene Expression Reveal a Temporally Orchestrated Wound Healing Response in the Injured Spinal Cord. J. Neurosci. 24: 8562-8576 [Abstract] [Full Text]  
• Fathke, C., Wilson, L., Hutter, J., Kapoor, V., Smith, A., Hocking, A., Isik, F. (2004). Contribution of Bone Marrow-Derived Cells to Skin: Collagen Deposition and Wound Repair. Stem Cells 22: 812-822 [Abstract] [Full Text]  
• Wilgus, T. A., Bergdall, V. K., Tober, K. L., Hill, K. J., Mitra, S., Flavahan, N. A., Oberyszyn, T. M. (2004). The Impact of Cyclooxygenase-2 Mediated Inflammation on Scarless Fetal Wound Healing. Am. J. Pathol. 165: 753-761 [Abstract] [Full Text]