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Correspondence
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Volume 341:766-767 September 2, 1999 Number 10
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The Pathogenesis of Melanoma Induced by Ultraviolet Radiation

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 by Gilchrest, B. A.
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To the Editor: In their otherwise admirable review of the pathogenesis of melanoma (April 29 issue),1 Gilchrest et al. misrepresent some of the epidemiologic evidence. The authors cite a paper I coauthored2 to indicate that incidence is inversely related to latitude of residence. The point of the paper was that the stronger relation is with latitude of residence during the first 20 to 30 years of life, decades before the diagnosis of the tumor in most patients.

Although the authors correctly (in my view) interpret the evidence that melanomas result from intermittent intense exposure to reflect, in actuality, that melanomas . . . [Full Text of this Article]

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