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Previous Volume 341:807-813 September 9, 1999 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The long-term survival of donor lymphoid cells in recipients of solid-organ transplants or of fetal lymphocytes that cross the placenta and enter the maternal circulation has been established,^1,2,3 but the fate of other hematopoietic progenitors in organ allografts, especially those of the myeloid lineage, is not known. We describe a case in which acute promyelocytic leukemia developed in a recipient of a liver transplant two years after transplantation. The leukemic clone had genetic and phenotypic markers of the donor, a previously healthy 16-year-old boy who died of a head injury. Our findings indicate that leukemic transformation of donor myeloid cells . . . [Full Text of this Article]

Case Report

Methods

Tissue Samples

Cytogenetic Analysis

DNA and RNA Extraction

Assay for Variable Number of Tandem Repeats and Molecular HLA Typing

Analysis by Reverse-Transcription PCR

Immunohistochemical Analysis

Fluorescence in Situ Hybridization

Results

Cytogenetic Analysis

VNTR Assay

RT-PCR Analysis

Molecular HLA Typing

Immunohistochemical Analysis and Fluorescence in Situ Hybridization

Discussion

Source Information

From the Departments of Medicine (I.B., M.P., M.B., S.N., R.B., J.D., D.A.), Pathology (J.H.), Pediatrics (M.S.W., R.V.R.), and Surgery (J.A.L.), Washington University School of Medicine, St. Louis; and the Fred Hutchinson Cancer Research Center, Seattle (J.P.R.).

Address reprint requests to Dr. Bodó at Euro-Med-Net, 5-7 Gyóri Ut., Budapest H-1123, Hungary, or at bodoimre@elender.hu.

References

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• Zhang, Y., Holford, T. R., Leaderer, B., Boyle, P., Zahm, S. H., Owens, P. H., Morton, L. M., Zhang, B., Zou, K., Flynn, S., Tallini, G., Zheng, T. (2004). Blood Transfusion and Risk of Non-Hodgkin's Lymphoma in Connecticut Women. Am J Epidemiol 160: 325-330 [Abstract] [Full Text]  
• Au, W.Y., Hung, K.N., Loong, F., Ma, S.K. (2003). Patients Presenting With CNS Lesions: CASE 3. SEQUENTIAL MYELOPROLIFERATIVE DISEASE AND GLIOBLASTOMA MULTIFORME IN A RENAL TRANSPLANT RECIPIENT. JCO 21: 4062-4063 [Full Text]  
• Chow, E. J., Holly, E. A. (2002). Blood Transfusions and Non-Hodgkin's Lymphoma. Epidemiol Rev 24: 269-279 [Full Text]  
• Chow, E. J., Holly, E. A. (2002). Blood Transfusions as a Risk Factor for Non-Hodgkin's Lymphoma in the San Francisco Bay Area: A Population-based Study. Am J Epidemiol 155: 725-731 [Abstract] [Full Text]  
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