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Previous Volume 341:837-839 September 9, 1999 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In this issue of the Journal, Takala et al.¹ report an increase in mortality among critically ill patients treated with growth hormone. This finding is of major importance and will generate considerable debate. The results of the two well-designed, multicenter trials described by Takala et al. call into question the safety of growth hormone therapy in critically ill patients. Previous studies showed that growth hormone in such patients was beneficial or at least did not differ from placebo.

We need to compare these two excellent studies carefully with previous trials in order to explain the difference in results. In the . . . [Full Text of this Article]

References

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• FERNANDEZ, M., MEDINA, A., SANTOS, F., CARBAJO, E., RODRIGUEZ, J., ALVAREZ, J., COBO, A. (2001). Exacerbated Inflammatory Response Induced by Insulin-Like Growth Factor I Treatment in Rats with Ischemic Acute Renal Failure. J. Am. Soc. Nephrol. 12: 1900-1907 [Abstract] [Full Text]  
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