The past two decades have witnessed an increase in the numberof patients who are immunocompromised as a consequence of aprimary or secondary immunodeficiency disorder or from the useof agents that depress one or more components of the immunesystem. Broadly defined, an immunocompromised host has an alterationin phagocytic, cellular, or humoral immunity that increasesthe risk of an infectious complication or an opportunistic processsuch as a lymphoproliferative disorder or cancer.1 Patientsmay also be immunocompromised if they have an alteration orbreach of their skin or mucosal defense barriers that permitsmicroorganisms to cause either . . . [Full Text of this Article]
Fever, Immunosuppression, and Infection
Need for Urgent Evaluation and Intervention
Dominant Organisms Associated with Infection
Initial Evaluation of Fever
Management of Infectious Complications
Source Information
From the Department of Medicine, Children's Hospital, and the Department of Pediatrics, Harvard Medical School both in Boston.
Address reprint requests to Dr. Pizzo at Children's Hospital, 300 Longwood Ave., Boston, MA 02115, or at pizzo_p@a1.tch.harvard.edu.
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