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Volume 341:921-922 September 16, 1999 Number 12
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Death after Transplantation of a Liver from a Donor with Unrecognized Ornithine Transcarbamylase Deficiency

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 by Lowance, D.
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To the Editor: Ornithine transcarbamylase deficiency is the most common inherited disorder of the urea cycle.1,2 It is an X-linked disease that can range in severity from hyperammonemic coma in neonates to the absence of symptoms in adults.1,2 Liver transplantation is an effective treatment for patients with this disease.3 However, this disease has another implication for liver transplantation, as demonstrated by the following case.

In December 1998, a 65-year-old woman underwent orthotopic liver transplantation for liver cirrhosis related to hepatitis C infection and hepatocellular carcinoma. She was extubated on the first postoperative day and initially did well (Table 1. . . [Full Text of this Article]

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