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Volume 341:1003-1004 September 23, 1999 Number 13
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Transient Acute Depression Induced by High-Frequency Deep-Brain Stimulation

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 by Bejjani, B.-P.
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To the Editor: Bejjani et al. (May 13 issue)1 reported the induction of transient acute depression by stimulation of the left subthalamic nucleus in a woman with Parkinson's disease. We have found that pallidotomy may also cause depression in patients with this disease. Among 41 patients (25 men and 16 women; mean age at operation, 60 years) with severe, chronic Parkinson's disease, 17 underwent left-sided pallidotomy, 13 right-sided pallidotomy, and 11 bilateral pallidotomy. All the patients improved after surgery. Persistent major depression, as defined by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition,2 developed immediately after the surgical . . . [Full Text of this Article]

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