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Correspondence
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Volume 341:998-1000 September 23, 1999 Number 13
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Treatment of Ductal Carcinoma in Situ

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 by Silverstein, M. J.
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To the Editor: The article by Silverstein et al. (May 13 issue)1 on the influence of margin width on local recurrence in patients with ductal carcinoma in situ who were treated with breast-conserving therapy provides no data showing that margins (of any size) were associated with outcome in their patients. The authors define subgroups of patients according to margin width without ever proving that margins were statistically important in univariate or multivariate analysis. We are left to guess whether margins were related to outcome as a continuous variable and how the three subgroups of patients (defined according to margin width) . . . [Full Text of this Article]

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