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Previous Volume 341:1021-1028 September 30, 1999 Number 14 Next

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ABSTRACT

Background The construction of subendocardial channels to perfuse ischemic areas of the myocardium has been investigated since the 1950s. We assessed the safety and efficacy of transmyocardial revascularization with a carbon dioxide laser in patients with refractory angina and left ventricular free-wall ischemia that was not amenable to direct coronary revascularization.

Methods In a prospective, controlled, multicenter trial, we randomly assigned 91 patients to undergo transmyocardial revascularization and 101 patients to receive continued medical treatment. The severity of angina (according to the Canadian Cardiovascular Society [CCS] classification), quality of life, and cardiac perfusion (as assessed by thallium-201 scanning) were evaluated at base line and 3, 6, and 12 months after randomization.

Results At 12 months, angina had improved by at least two CCS classes in 72 percent of the patients assigned to transmyocardial revascularization, as compared with 13 percent of the patients assigned to medical treatment who continued medical treatment (P<0.001). Patients in the transmyocardial-revascularization group also had a significantly improved quality of life as compared with the medical-treatment group. Myocardial perfusion improved by 20 percent in the transmyocardial-revascularization group and worsened by 27 percent in the medical-treatment group (P=0.002). In the first year of follow-up, 2 percent of patients assigned to undergo transmyocardial revascularization were hospitalized because of unstable angina, as compared with 69 percent of patients assigned to medical treatment (P<0.001). The perioperative mortality rate associated with transmyocardial revascularization was 3 percent. The rate of survival at 12 months was 85 percent in the transmyocardial-revascularization group and 79 percent in the medical-treatment group (P=0.50).

Conclusions In patients with angina refractory to medical treatment and coronary artery disease that precluded coronary-artery bypass surgery or percutaneous transluminal coronary angioplasty, transmyocardial revascularization improved cardiac perfusion and clinical status over a 12-month period.

Source Information

From the Department of Cardiovascular Surgery and Research, Texas Heart Institute, Houston (O.H.F.); the Department of Cardiovascular Surgery, Rush–Presbyterian–St. Luke's Medical Center, Chicago (R.J.M.); and the Division of Cardiothoracic Surgery, Northwestern University Medical School, Chicago (K.A.H.).

Address reprint requests to Dr. Frazier at the Texas Heart Institute, P.O. Box 20345, Houston, TX 77225-0345.

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• Johnson, L. L., Thambar, S., Donahay, T., Dae, M., Williams, D. O. (2002). Effect of Endomyocardial Laser Channels on Regional Innervation Shown with 125I-MIBG and Autoradiography. JNM 43: 551-555 [Abstract] [Full Text]  
• Kim, M. C., Kini, A., Sharma, S. K. (2002). Refractory angina pectoris: Mechanism and therapeutic options. J Am Coll Cardiol 39: 923-934 [Abstract] [Full Text]  
• Mannheimer, C., Camici, P., Chester, M.R., Collins, A., DeJongste, M., Eliasson, T., Follath, F., Hellemans, I., Herlitz, J., Luscher, T., Pasic, M., Thelle, D. (2002). The problem of chronic refractory angina. Report from the ESC Joint Study Group on the Treatment of Refractory Angina. Eur Heart J 23: 355-370 [Full Text]  
• Cotton, J M, Thomas, M R, Dunmore, B J, Salisbury, J, Shah, A M, Brindle, N P J (2002). Angiogenesis in chronically ischaemic human heart following percutaneous myocardial revascularisation. Heart 87: 281-283 [Full Text]  
• Lee, R., Fischer, K. C., Moon, M. R. (2002). Reoperative transmyocardial laser revascularization for late recurrent angina. Ann. Thorac. Surg. 73: 650-652 [Abstract] [Full Text]  
• Laham, R. J., Simons, M., Pearlman, J. D., Ho, K. K. L., Baim, D. S. (2002). Magnetic resonance imaging demonstrates improved regional systolic wall motion and thickening and myocardial perfusion of myocardial territories treated by laser myocardial revascularization. J Am Coll Cardiol 39: 1-8 [Abstract] [Full Text]  
• Freedman, S. B., Isner, J. M. (2002). Therapeutic Angiogenesis for Coronary Artery Disease. ANN INTERN MED 136: 54-71 [Abstract] [Full Text]  
• Horvath, K. A., Belkind, N., Wu, I., Greene, R., Doukas, J., Lomasney, J. W., McPherson, D. D., Fullerton, D. A. (2001). Functional comparison of transmyocardial revascularization by mechanical and laser means. Ann. Thorac. Surg. 72: 1997-2002 [Abstract] [Full Text]  
• Chaubey, S, Davies, S., Moat, N (2001). Invasive investigations and revascularisation: Ischaemic heart disease. Br Med Bull 59: 45-53 [Abstract] [Full Text]  
• Burkhoff, D., Jones, J. W., Becker, L. C. (2001). Variability of myocardial perfusion defects assessed by thallium-201 scintigraphy in patients with coronary artery disease not amenable to angioplasty or bypass surgery. J Am Coll Cardiol 38: 1033-1039 [Abstract] [Full Text]  
• Horvath, K. A. (2001). Shedding light on denervation and transmyocardial laser revascularization. J. Thorac. Cardiovasc. Surg. 122: 647-648 [Full Text]  
• Minisi, A. J., Topaz, O., Quinn, M. S., Mohanty, L. B. (2001). Cardiac nociceptive reflexes after transmyocardial laser revascularization: Implications for the neural hypothesis of angina relief. J. Thorac. Cardiovasc. Surg. 122: 712-719 [Abstract] [Full Text]  
• Mohlenkamp, S., Behrenbeck, T. R., Lerman, A., Lerman, L. O., Pankratz, V. S., Sheedy, P. F. II, Weaver, A. L., Ritman, E. L. (2001). Coronary Microvascular Functional Reserve: Quantification of Long-term Changes with Electron-Beam CT—Preliminary Results in a Porcine Model. Radiology 221: 229-236 [Abstract] [Full Text]  
• Horvath, K. A., Aranki, S. F., Cohn, L. H., March, R. J., Frazier, O. H., Kadipasaoglu, K. A., Boyce, S. W., Lytle, B. W., Landolfo, K. P., Lowe, J. E., Hattler, B., Griffith, B. P., Lansing, A. M. (2001). Sustained Angina Relief 5 Years After Transmyocardial Laser Revascularization With a CO2 Laser. Circulation 104: I-81-84 [Abstract] [Full Text]  
• Arora, R. C., Hirsch, G. M., Hirsch, K., Armour, J. A. (2001). Transmyocardial Laser Revascularization Remodels the Intrinsic Cardiac Nervous System in a Chronic Setting. Circulation 104: I-115-120 [Abstract] [Full Text]  
• Hamawy, A. H., Lee, L. Y., Samy, S. A., Polce, D. R., Szulc, M., Vazquez, M., Rosengart, T. K. (2001). Transmyocardial laser revascularization dose response: enhanced perfusion in a porcine ischemia model as a function of channel density. Ann. Thorac. Surg. 72: 817-822 [Abstract] [Full Text]  
• Campbell, H.E., Tait, S., Buxton, M.J., Sharples, L.D., Caine, N., Schofield, P.M., Wallwork, J. (2001). A UK trial-based cost-utility analysis of transmyocardial laser revascularization compared to continued medical therapy for treatment of refractory angina pectoris. Eur. J. Cardiothorac. Surg. 20: 312-318 [Abstract] [Full Text]  
• Patil, C.V, Nikolsky, E, Boulos, M, Grenadier, E, Beyar, R (2001). Multivessel coronary artery disease: current revascularization strategies. Eur Heart J 22: 1183-1197  
• Zvara, D. A. (2001). Treatment of Perioperative Myocardial Ischemia. SEMIN CARDIOTHORAC VASC ANESTH 5: 166-183 [Abstract]  
• Tabibiazar, R, Rockson, S.G (2001). Angiogenesis and the ischaemic heart. Eur Heart J 22: 903-918  
• Oesterle, S. N., Reifart, N., Hauptmann, E., Hayase, M., Yeung, A. C. (2001). Percutaneous In Situ Coronary Venous Arterialization : Report of the First Human Catheter-Based Coronary Artery Bypass. Circulation 103: 2539-2543 [Abstract] [Full Text]  
• Vale, P. R., Losordo, D. W., Milliken, C. E., McDonald, M. C., Gravelin, L. M., Curry, C. M., Esakof, D. D., Maysky, M., Symes, J. F., Isner, J. M. (2001). Randomized, Single-Blind, Placebo-Controlled Pilot Study of Catheter-Based Myocardial Gene Transfer for Therapeutic Angiogenesis Using Left Ventricular Electromechanical Mapping in Patients With Chronic Myocardial Ischemia. Circulation 103: 2138-2143 [Abstract] [Full Text]  
• Allen, K. B., Dowling, R. D., Shaar, C. J. (2001). Reply. J. Thorac. Cardiovasc. Surg. 121: 601-603 [Full Text]  
• Post, M. J., Laham, R., Sellke, F. W., Simons, M. (2001). Therapeutic angiogenesis in cardiology using protein formulations. Cardiovasc Res 49: 522-531 [Abstract] [Full Text]  
• Fuchs, S., Kornowski, R. (2001). Transepicardial or transendocardial injury: controversies regarding angiogenic potential and mechanism of action. Cardiovasc Res 49: 582-587 [Full Text]  
• Dzau, V. J., Mann, M. J., Ehsan, A., Griese, D. P. (2001). Gene therapy and genomic strategies for cardiovascular surgery: The emerging field of surgiomics. J. Thorac. Cardiovasc. Surg. 121: 0206-216 [Full Text]  
• Simons, M., Bonow, R. O., Chronos, N. A., Cohen, D. J., Giordano, F. J., Hammond, H. K., Laham, R. J., Li, W., Pike, M., Sellke, F. W., Stegmann, T. J., Udelson, J. E., Rosengart, T. K. (2000). Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus : An Expert Panel Summary. Circulation 102 : e73-e86 [Abstract] [Full Text]  
• Kornowski, R., Baim, D. S., Moses, J. W., Hong, M. K., Laham, R. J., Fuchs, S., Hendel, R. C., Wallace, D., Cohen, D. J., Bonow, R. O., Kuntz, R. E., Leon, M. B. (2000). Short- and Intermediate-Term Clinical Outcomes From Direct Myocardial Laser Revascularization Guided by Biosense Left Ventricular Electromechanical Mapping. Circulation 102: 1120-1125 [Abstract] [Full Text]  
• Hughes, G. C., Kypson, A. P., Annex, B. H., Yin, B., St. Louis, J. D., Biswas, S. S., Coleman, R. E., DeGrado, T. R., Donovan, C. L., Landolfo, K. P., Lowe, J. E. (2000). Induction of angiogenesis after TMR: a comparison of holmium:YAG, CO2, and excimer lasers. Ann. Thorac. Surg. 70: 504-509 [Abstract] [Full Text]  
• Lutter, G., Martin, J., Dern, P., Sarai, K., Olschewski, M., von Samson, P., Burkle, M., Beyersdorf, F. (2000). Evaluation of the indirect revascularization method after 3 months chronic myocardial ischemia. Eur. J. Cardiothorac. Surg. 18: 38-45 [Abstract] [Full Text]  
• (2000). Additional articles abstracted in ACP Journal Club. Evid. Based Med. 5: 67-67 [Full Text]  
• Aaberge, L., Nordstrand, K., Dragsund, M., Saatvedt, K., Endresen, K., Golf, S., Geiran, O., Abdelnoor, M., Forfang, K. (2000). Transmyocardial revascularization with CO2 laser in patients with refractory angina pectoris: Clinical results from The Norwegian Randomized Trial. J Am Coll Cardiol 35: 1170-1177 [Abstract] [Full Text]  
• Allen, K. B., Dowling, R. D., DelRossi, A. J., Realyvasques, F., Lefrak, E. A., Pfeffer, T. A., Fudge, T. L., Mostovych, M., Schuch, D., Szentpetery, S., Shaar, C. J. (2000). TRANSMYOCARDIAL LASER REVASCULARIZATION COMBINED WITH CORONARY ARTERY BYPASS GRAFTING: A MULTICENTER, BLINDED, PROSPECTIVE, RANDOMIZED, CONTROLLED TRIAL. J. Thorac. Cardiovasc. Surg. 119: 540-549 [Abstract] [Full Text]  
• CLARKE, S. C, SCHOFIELD, P. M (2000). Percutaneous myocardial laser revascularisation. Heart 83: 253-254 [Full Text]  
• Downing, S. W., Williams, S. G., Wright, D. J., Tan, L. B., Frazier, O.H., March, R. J., Horvath, K. A., Allen, K. B., Lange, R. A., Hillis, L. D. (2000). Transmyocardial Laser Revascularization. NEJM 342: 436-438 [Full Text]  
• Bridges, C. R. (2000). Myocardial laser revascularization: the controversy and the data. Ann. Thorac. Surg. 69: 655-662 [Abstract] [Full Text]  
• (1999). Transmyocardial Revascularization for Refractory Angina. JWatch General 1999: 2-2 [Full Text]  
• Lange, R. A., Hillis, L. D. (1999). Transmyocardial Laser Revascularization. NEJM 341: 1074-1076 [Full Text]  
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