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Previous Volume 341:1081-1082 September 30, 1999 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Guinan et al. (June 3 issue)¹ reported an interesting method for preventing graft-versus-host disease after bone marrow transplantation. CTLA-4–Ig was added to a culture of a mixture of irradiated mononuclear cells from the recipient and marrow cells from the donor. After 36 hours, the recipient and donor cells were infused into the patient. The incidence of graft-versus-host disease after transplantation of haploidentical bone marrow (from a donor mismatched with the recipient for one HLA haplotype) was lower than expected. The authors attribute the inhibition of alloreactivity to anergy of the donor T cells, mediated by blockade of . . . [Full Text of this Article]

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