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Previous Volume 341:1206-1216 October 14, 1999 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Growth hormone is produced by the somatotroph cells of the anterior pituitary. Its secretion is stimulated by growth hormone–releasing hormone and inhibited by somatostatin, which are both produced by the hypothalamus. Growth hormone secretion is pulsatile, and the amplitude of the pulses is greatest at night. Twenty-four-hour growth hormone secretion is maximal during puberty and declines gradually thereafter in both women and men. Growth hormone acts by binding to receptors on liver cells and other cells. One growth hormone molecule binds to two receptor molecules on the target cell, initiating a cascade of events that results in the secretion of . . . [Full Text of this Article]

Growth Hormone–Replacement Therapy in Adults

Causes of Growth Hormone Deficiency in Adults

Diagnosis of Growth Hormone Deficiency

Clinical Manifestations

Response to Growth Hormone

Side Effects

Dose of Growth Hormone

Other Uses of Growth Hormone in Adults

Growth Hormone Therapy in Children

Definition of Growth Hormone Deficiency in Children

Causes of Growth Hormone Deficiency and Its Variants in Children

            Congenital Growth Hormone Deficiency

            Acquired Growth Hormone Deficiency

            Chronic Renal Insufficiency

            Turner's Syndrome

Treatment Indications and Response to Growth Hormone

            Classic Growth Hormone Deficiency

            Chronic Renal Insufficiency

            Turner's Syndrome

Idiopathic Short Stature

Other Conditions Impairing Growth

Transition from Adolescence to Adulthood

Adverse Effects

Conclusions

Source Information

From the Department of Internal Medicine, University of Virginia Medical Center, Charlottesville (M.L.V.), and the Nemours Children's Clinic, Jacksonville, Fla. (N.M.).

Address reprint requests to Dr. Vance at Box 601, University of Virginia Medical Center, Charlottesville, VA 22908, or to Dr. Mauras at the Nemours Children's Clinic, 807 Nira St., Jacksonville, FL 32207.

References

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