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Editorial
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Volume 341:1226-1227 October 14, 1999 Number 16
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Exogenous Reinfection in Tuberculosis

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 by van Rie, A.
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Tuberculosis, like all infectious diseases, involves exposure to a pathogen resulting in an asymptomatic period of incubation or latency that may progress to active disease. Unlike most other infectious diseases, tuberculosis involves a delay between infection and disease that is extremely variable, ranging from a few weeks to a lifetime. Therefore, the development of active tuberculosis in someone known to have been previously infected raises the question whether this represents a recrudescence of the initially infecting organism (endogenous reactivation) or a new strain of Mycobacterium tuberculosis (exogenous reinfection).

For decades, this question has been central to a debate in which . . . [Full Text of this Article]

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