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Editorial
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Volume 341:1227-1229 October 14, 1999 Number 16
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Immune Reconstitution

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 by Markert, M. L.
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In this issue of the Journal, Markert et al.1 teach us that transplanting pieces of human thymus can rescue children with the DiGeorge syndrome. Complete DiGeorge syndrome is a rare congenital disorder in which the thymus and parathyroids fail to develop; the result is long-lasting T-cell deficiency. It is a medical and scientific triumph that transplantations of fetal or postneonatal thymus fragments can lead to T-cell neogenesis, the achievement of T-cell immune competence, and, for some patients, the ability to live at home in an otherwise hostile microbial environment.

Although the disease is rare, it represents a unique opportunity to . . . [Full Text of this Article]

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