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Previous Volume 341:1284-1291 October 21, 1999 Number 17 Next

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BehÇet's disease is an inflammatory disorder of unknown cause, characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions.^1,2 All these common manifestations are self-limiting except for the ocular attacks. Repeated attacks of uveitis can cause blindness.^1,2,3 Behçet's disease is not a chronic, persistent inflammatory disease, but rather one consisting of recurrent attacks of acute inflammation. Involvement of the gastrointestinal tract, central nervous system, and large vessels is less frequent (Table 1), although it can be life-threatening.^1,2,4,5,6 Susceptibility to Behçet's disease is strongly associated with the presence of the HLA-B51 allele.^7,8 Environmental factors such as infectious . . . [Full Text of this Article]

Epidemiology

Causation

Pathophysiology

Diagnosis

Clinical Manifestations

Treatment

Mucocutaneous Lesions

Ocular Lesions

Arthritis

Gastrointestinal Lesions

Central Nervous System Lesions

Large-Vessel Involvement

Conclusions

Source Information

From the Departments of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki (T.S., M.T., N.S.); and the Department of Ophthalmology, Uveitis Clinic, Tokyo Women's Medical College and Daini Hospital, Tokyo (G.I.) — all in Japan.

Address reprint requests to Dr. Sakane at the Departments of Immunology and Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan, or at t2sakane@marianna-u.ac.jp.

References

Related Letters:

Behçet's Disease
Agca M., Nzerue C. M., Ehrlich G. E., Drenth J. P.H., Livneh A., Haznedaroglu I. C., Özcebe O. I., Dündar S. V., Cheng T. O., Sakane T., Takeno M., Suzuki N.
Extract | Full Text  
N Engl J Med 2000; 342:587-589, Feb 24, 2000. Correspondence

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