In the United States, an estimated 20,000 new cases of liverand biliary tract cancer are diagnosed annually.1 Biliary tractcancer is the second most common primary hepatobiliary cancer,after hepatocellular cancer. Approximately 7500 new cases ofbiliary tract cancer are diagnosed per year; about 5000 of theseare gallbladder cancer, and between 2000 and 3000 are bile-ductcancers.1 Biliary tract cancers have traditionally been dividedinto cancers of the gallbladder, the extrahepatic bile ducts,and the ampulla of Vater, whereas intrahepatic bile-duct cancershave been classified as primary liver cancers.2 The term "cholangiocarcinoma"was originally intended to refer only . . . [Full Text of this Article]
Pathological Features
Risk Factors
Molecular Aspects
Diagnosis
Treatment and Survival
Surgery
Radiation
Chemotherapy
Other Palliative Treatments
Future Directions
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From the Mayo Clinic, Rochester, Minn.
Address reprint requests to Dr. de Groen at the Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905.
References
Related Letters:
Biliary Tract Cancers
Figueras J., Valls C., Jaurrieta E., de Groen P. C.
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N Engl J Med 2000;
342:663-664, Mar 2, 2000.
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Fiorentino, M., Altimari, A., D'Errico, A., Gabusi, E., Chieco, P., Masetti, M., Grigioni, W. F.
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132: 1006-1007
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