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Volume 341:1396-1397 October 28, 1999 Number 18
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Hydrogenated Fats and Serum Cholesterol Levels

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 by Lichtenstein, A. H.
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 by Ascherio, A.
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To the Editor: In their article on hydrogenated fats and serum cholesterol levels, Lichtenstein et al. (June 24 issue)1 apparently did not consider variations in the ratio of polyunsaturated to saturated fatty acids (P:S) in the six experimental diets. The P:S ratio is well established as a mediator of serum cholesterol concentrations.2,3 Linear regression analysis shows that the P:S ratio in each of the five diets containing vegetable oil (calculated on the basis of data in Table 3 in the article by Lichtenstein et al.) explains considerably more of the variation in total cholesterol, low-density lipoprotein (LDL) cholesterol, and the . . . [Full Text of this Article]

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