Transplacental Transmission of Natural-Killer-Cell Lymphoma
Elizabeth A. Catlin, M.D., Jesse D. Roberts, M.D., Rodrigo Erana, M.D., Frederic I. Preffer, Ph.D., Judith A. Ferry, M.D., Abigail S. Kelliher, B.A., Leonard Atkins, M.D., and Howard J. Weinstein, M.D.
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
The placenta is an organ of embryonic origin that supports thegrowing fetus by facilitating the transfer of nutrients fromthe mother. It is not well understood how the allogeneic fetusthrives and avoids immune rejection in an environment whereonly trophoblastic and fetal capillary basement membranes separatethe maternal and fetal circulations. Reports of vertical transmissionof cancer are exceptionally rare, although maternal cells doreach the fetus1,2 and cancer occurs in nearly 1 in 1000 pregnantwomen.3,4,5 Malignant melanoma is the best known example ofa cancer that can metastasize to the fetus. We report the transferto . . . [Full Text of this Article]
Case Reports
Mother
Infant
Methods
Light Microscopy
Immunohistochemical Analysis
In Situ Hybridization
Flow Cytometry
Results
Mother
Infant
Cytogenetic Analysis
Discussion
Source Information
From the Divisions of Neonatology (E.A.C., J.D.R.) and Hematology and Oncology (H.J.W.), Department of Pediatrics (R.E.), the Department of Pathology (F.I.P., J.A.F., A.S.K., L.A.), and the Department of Anesthesia and Critical Care (J.D.R.), Massachusetts General Hospital, Boston.
Address reprint requests to Dr. Weinstein at Blake 2, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, or at weinstein.howard@mgh.harvard.edu.
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