FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 341:1577-1581 November 18, 1999 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Corticotropin-independent Cushing's syndrome is usually caused by cortisol-secreting adrenal adenomas, carcinomas, or (rarely) bilateral adrenal hyperplasia. In some patients with this syndrome, the excess secretion of cortisol is caused by abnormal adrenal expression and function of receptors for various hormones, including gastric inhibitory polypeptide,^1,2,3,4,5,6 vasopressin,^7,8,9 ß-adrenergic agonists,¹⁰ and interleukin-1.¹¹ These findings suggest that diverse other hormone receptors could be implicated in other patients.¹²

We describe a woman with bilateral adrenal hyperplasia and corticotropin-independent Cushing's syndrome that was clinically manifested transiently during her pregnancies and became constant only after menopause. The patient's cortisol secretion was stimulated by luteinizing hormone and chorionic . . . [Full Text of this Article]

Case Report

Methods

Clinical Studies

Assays

Results

Discussion

Source Information

From the Division of Endocrinology, Department of Medicine, Research Center, Hôtel-Dieu du Centre Hospitalier de l'Université de Montréal, Montreal.

Address reprint requests to Dr. Lacroix at the Research Center, Hôtel-Dieu du CHUM, 3850 St.-Urbain, Montreal, QC H2W 1T8, Canada, or at andre.lacroix@umontreal.ca.

References

This article has been cited by other articles:

• Vuorenoja, S., Rivero-Muller, A., Ziecik, A. J, Huhtaniemi, I., Toppari, J., Rahman, N. A (2008). Targeted therapy for adrenocortical tumors in transgenic mice through their LH receptor by Hecate-human chorionic gonadotropin {beta} conjugate. Endocr Relat Cancer 15: 635-648 [Abstract] [Full Text]  
• Albiger, N M, Occhi, G, Mariniello, B, Iacobone, M, Favia, G, Fassina, A, Faggian, D, Mantero, F, Scaroni, C (2007). Food-dependent Cushing's syndrome: from molecular characterization to therapeutical results. Eur J Endocrinol 157: 771-778 [Abstract] [Full Text]  
• Kuijten, A. M., Schoemaker, N. J., Voorhout, G. (2007). Ultrasonographic Visualization of the Adrenal Glands of Healthy Ferrets and Ferrets With Hyperadrenocorticism. Journal of the American Animal Hospital Association 43: 78-84 [Abstract] [Full Text]  
• Klibanski, A., Stephen, A. E., Greene, M. F., Blake, M. A., Wu, C.-L. (2006). Case 36-2006 -- A 35-Year-Old Pregnant Woman with New Hypertension.. NEJM 355: 2237-2245 [Full Text]  
• Alevizaki, M., Saltiki, K., Mantzou, E., Anastasiou, E., Huhtaniemi, I. (2006). The adrenal gland may be a target of LH action in postmenopausal women.. Eur J Endocrinol 154: 875-881 [Abstract] [Full Text]  
• Saner-Amigh, K., Mayhew, B. A., Mantero, F., Schiavi, F., White, P. C., Rao, C. V., Rainey, W. E. (2006). Elevated Expression of Luteinizing Hormone Receptor in Aldosterone-Producing Adenomas. J. Clin. Endocrinol. Metab. 91: 1136-1142 [Abstract] [Full Text]  
• Mazzuco, T. L., Chabre, O., Feige, J.-J., Thomas, M. (2006). Aberrant Expression of Human Luteinizing Hormone Receptor by Adrenocortical Cells Is Sufficient to Provoke Both Hyperplasia and Cushing's Syndrome Features. J. Clin. Endocrinol. Metab. 91: 196-203 [Abstract] [Full Text]  
• Ascoli, M. (2005). Learning New Tricks from an Old Dog: The Processing of the Intracellular Precursor of the Luteinizing Hormone Receptor (LHR) into the Mature Cell-Surface LHR Is a Regulated Process. Endocrinology 146: 3221-3223 [Full Text]  
• Lindsay, J. R., Jonklaas, J., Oldfield, E. H., Nieman, L. K. (2005). Cushing's Syndrome during Pregnancy: Personal Experience and Review of the Literature. J. Clin. Endocrinol. Metab. 90: 3077-3083 [Abstract] [Full Text]  
• Swords, F. M., Aylwin, S., Perry, L., Arola, J., Grossman, A. B., Monson, J. P., Clark, A. J. L. (2005). The Aberrant Expression of the Gastric Inhibitory Polypeptide (GIP) Receptor in Adrenal Hyperplasia: Does Chronic Adrenocorticotropin Exposure Stimulate Up-Regulation of GIP Receptors in Cushing's Disease?. J. Clin. Endocrinol. Metab. 90: 3009-3016 [Abstract] [Full Text]  
• Dluhy, R. G., Maher, M. M., Wu, C.-L. (2005). Case 7-2005 - A 59-Year-Old Woman with an Incidentally Discovered Adrenal Nodule. NEJM 352: 1025-1032 [Full Text]  
• Rahman, N. A., Kiiveri, S., Rivero-Muller, A., Levallet, J., Vierre, S., Kero, J., Wilson, D. B., Heikinheimo, M., Huhtaniemi, I. (2004). Adrenocortical Tumorigenesis in Transgenic Mice Expressing the Inhibin {alpha}-Subunit Promoter/Simian Virus 40 T-Antigen Transgene: Relationship between Ectopic Expression of Luteinizing Hormone Receptor and Transcription Factor GATA-4. Mol. Endocrinol. 18: 2553-2569 [Abstract] [Full Text]  
• Rao, Ch.V., Zhou, X.L., Lei, Z.M. (2004). Functional Luteinizing Hormone/Chorionic Gonadotropin Receptors in Human Adrenal Cortical H295R Cells. Biol. Reprod. 71: 579-587 [Abstract] [Full Text]  
• Mannelli, M., Ferruzzi, P., Luciani, P., Crescioli, C., Buci, L., Corona, G., Serio, M., Peri, A. (2003). Cushing's Syndrome in a Patient with Bilateral Macronodular Adrenal Hyperplasia Responding to Cisapride: An in Vivo and in Vitro Study. J. Clin. Endocrinol. Metab. 88: 4616-4622 [Abstract] [Full Text]  
• Beuschlein, F., Looyenga, B. D., Bleasdale, S. E., Mutch, C., Bavers, D. L., Parlow, A. F., Nilson, J. H., Hammer, G. D. (2003). Activin Induces x-Zone Apoptosis That Inhibits Luteinizing Hormone-Dependent Adrenocortical Tumor Formation in Inhibin-Deficient Mice. Mol. Cell. Biol. 23: 3951-3964 [Abstract] [Full Text]  
• Fragoso, M. C. B. V., Domenice, S., Latronico, A. C., Martin, R. M., Pereira, M. A. A., Zerbini, M. C. N., Lucon, A. M., Mendonca, B. B. (2003). Cushing's Syndrome Secondary to Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia due to Activating Mutations of GNAS1 Gene. J. Clin. Endocrinol. Metab. 88: 2147-2151 [Abstract] [Full Text]  
• Goodarzi, M. O., Dawson, D. W., Li, X., Lei, Z., Shintaku, P., Rao, C. V., Van Herle, A. J. (2003). Virilization in Bilateral Macronodular Adrenal Hyperplasia Controlled by Luteinizing Hormone. J. Clin. Endocrinol. Metab. 88: 73-77 [Abstract] [Full Text]  
• Feelders, R. A., Lamberts, S. W. J., Hofland, L. J., van Koetsveld, P. M., Verhoef-Post, M., Themmen, A. P. N., de Jong, F. H., Bonjer, H. J., Clark, A. J., van der Lely, A.-J., de Herder, W. W. (2003). Luteinizing Hormone (LH)-Responsive Cushing's Syndrome: The Demonstration of LH Receptor Messenger Ribonucleic Acid in Hyperplastic Adrenal Cells, which Respond to Chorionic Gonadotropin and Serotonin Agonists in Vitro. J. Clin. Endocrinol. Metab. 88: 230-237 [Abstract] [Full Text]  
• Cartier, D., Lihrmann, I., Parmentier, F., Bastard, C., Bertherat, J., Caron, P., Kuhn, J.-M., Lacroix, A., Tabarin, A., Young, J., Vaudry, H., Lefebvre, H. (2003). Overexpression of Serotonin4 Receptors in Cisapride-Responsive Adrenocorticotropin-Independent Bilateral Macronodular Adrenal Hyperplasia Causing Cushing's Syndrome. J. Clin. Endocrinol. Metab. 88: 248-254 [Abstract] [Full Text]  
• Mann, R. J., Keri, R. A., Nilson, J. H. (2003). Consequences of Elevated Luteinizing Hormone on Diverse Physiological Systems: Use of the LH{beta}CTP Transgenic Mouse as a Model of Ovarian Hyperstimulation-induced Pathophysiology. Recent Prog Horm Res 58: 343-375 [Abstract] [Full Text]  
• Mune, T., Murase, H., Yamakita, N., Fukuda, T., Murayama, M., Miura, A., Suwa, T., Hanafusa, J., Daido, H., Morita, H., Yasuda, K. (2002). Eutopic Overexpression of Vasopressin V1a Receptor in Adrenocorticotropin-Independent Macronodular Adrenal Hyperplasia. J. Clin. Endocrinol. Metab. 87: 5706-5713 [Abstract] [Full Text]  
• KIRSCHNER, L. S. (2002). Signaling Pathways in Adrenocortical Cancer. Ann. N. Y. Acad. Sci. 968: 222-239 [Abstract] [Full Text]  
• BOURDEAU, I., STRATAKIS, C. A. (2002). Cyclic AMP-Dependent Signaling Aberrations in Macronodular Adrenal Disease. Ann. N. Y. Acad. Sci. 968: 240-255 [Abstract] [Full Text]  
• Bourdeau, I., Bard, C., Noel, B., Leclerc, I., Cordeau, M.-P., Belair, M., Lesage, J., Lafontaine, L., Lacroix, A. (2002). Loss of Brain Volume in Endogenous Cushing's Syndrome and Its Reversibility after Correction of Hypercortisolism. J. Clin. Endocrinol. Metab. 87: 1949-1954 [Abstract] [Full Text]  
• Groussin, L., Perlemoine, K., Contesse, V., Lefebvre, H., Tabarin, A., Thieblot, P., Schlienger, J. L., Luton, J. P., Bertagna, X., Bertherat, J. (2002). The Ectopic Expression of the Gastric Inhibitory Polypeptide Receptor Is Frequent in Adrenocorticotropin-Independent Bilateral Macronodular Adrenal Hyperplasia, but Rare in Unilateral Tumors. J. Clin. Endocrinol. Metab. 87: 1980-1985 [Abstract] [Full Text]  
• Ascoli, M., Fanelli, F., Segaloff, D. L. (2002). The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective. Endocr. Rev. 23: 141-174 [Abstract] [Full Text]  
• Bourdeau, I., D'Amour, P., Hamet, P., Boutin, J.-M., Lacroix, A. (2001). Aberrant Membrane Hormone Receptors in Incidentally Discovered Bilateral Macronodular Adrenal Hyperplasia with Subclinical Cushing's Syndrome. J. Clin. Endocrinol. Metab. 86: 5534-5540 [Abstract] [Full Text]  
• Khardori, R., Boscaro, M., Barzon, L., Sonino, N. (2001). Considerations in Diagnosis of Cushing Syndrome. Arch Intern Med 161: 1780-1780 [Full Text]  
• Lacroix, A., N'Diaye, N., Tremblay, J., Hamet, P. (2001). Ectopic and Abnormal Hormone Receptors in Adrenal Cushing's Syndrome. Endocr. Rev. 22: 75-110 [Abstract] [Full Text]  
• Tsagarakis, S., Tsigos, C., Vassiliou, V., Tsiotra, P., Pratsinis, H., Kletsas, D., Trivizas, P., Nikou, A., Mavromatis, T., Sotsiou, F., Raptis, S., Thalassinos, N. (2001). Food-Dependent Androgen and Cortisol Secretion by a Gastric Inhibitory Polypeptide-Receptor Expressive Adrenocortical Adenoma Leading to Hirsutism and Subclinical Cushing's Syndrome: In Vivo and in Vitro Studies. J. Clin. Endocrinol. Metab. 86: 583-589 [Abstract] [Full Text]  
• Mircescu, H., Jilwan, J., N'Diaye, N., Bourdeau, I., Tremblay, J., Hamet, P., Lacroix, A. (2000). Are Ectopic or Abnormal Membrane Hormone Receptors Frequently Present in Adrenal Cushing's Syndrome?. J. Clin. Endocrinol. Metab. 85: 3531-3536 [Abstract] [Full Text]