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Correspondence
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Volume 341:1772 December 2, 1999 Number 23
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Metastasizing Aggressive Angiomyxoma

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To the Editor: Aggressive angiomyxoma is a rare myofibroblastic tumor that arises mainly in the perineum and genitalia in premenopausal women. Histologically, the tumor has a monomorphic pattern, with small, spindle-shaped mesenchymal cells dispersed in a loose, myxoid matrix and a characteristic vascular component. Cellularity is generally low, and mitoses are not seen. Despite this innocuous-looking histologic pattern, angiomyxoma has a strong tendency to be locally aggressive, with infiltrative growth and local recurrence.1 In approximately 100 documented cases, however, no evidence of distant metastasis has been reported. We describe a case of aggressive angiomyxoma of the pelvis that metastasized to . . . [Full Text of this Article]

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