Miltefosine was originally developed as an antineoplastic drug,but it has the potential to become the first highly effective,orally administered drug for treating visceral leishmaniasis,a life-threatening parasitic disease. We do not know whetheradditional clinical trials and experience with miltefosine willsupport the encouraging findings of the phase 2 study describedby Jha et al. in this issue of the Journal.1 However, the prospectof a new drug that is administered orally rather than parenterallyis good news indeed, because the drug could markedly facilitatethe treatment of patients.
Verma, N. K., Dey, C. S.
(2004). Possible Mechanism of Miltefosine-Mediated Death of Leishmania donovani. Antimicrob. Agents Chemother.
48: 3010-3015
[Abstract][Full Text]
Larabi, M., Yardley, V., Loiseau, P. M., Appel, M., Legrand, P., Gulik, A., Bories, C., Croft, S. L., Barratt, G.
(2003). Toxicity and Antileishmanial Activity of a New Stable Lipid Suspension of Amphotericin B. Antimicrob. Agents Chemother.
47: 3774-3779
[Abstract][Full Text]
Hanson, P. K., Malone, L., Birchmore, J. L., Nichols, J. W.
(2003). Lem3p Is Essential for the Uptake and Potency of Alkylphosphocholine Drugs, Edelfosine and Miltefosine. J. Biol. Chem.
278: 36041-36050
[Abstract][Full Text]
Patel, V., Lahusen, T., Sy, T., Sausville, E. A., Gutkind, J. S., Senderowicz, A. M.
(2002). Perifosine, a Novel Alkylphospholipid, Induces p21WAF1 Expression in Squamous Carcinoma Cells through a p53-independent Pathway, Leading to Loss in Cyclin-dependent Kinase Activity and Cell Cycle Arrest. Cancer Res.
62: 1401-1409
[Abstract][Full Text]
Herwaldt, B. L.
(2001). Laboratory-Acquired Parasitic Infections from Accidental Exposures. Clin. Microbiol. Rev.
14: 659-688
[Abstract][Full Text]
Sundar, S., Agrawal, G, Rai, M., Makharia, M K, Murray, H. W, Lockwood, D. N J
(2001). Treatment of Indian visceral leishmaniasis with single or daily infusions of low dose liposomal amphotericin B: randomised trial Commentary: cost and resistance remain issues. BMJ
323: 419-422
[Abstract][Full Text]
Eibl, H., Sherwood, J. A., Berman, J., Herwaldt, B. L.
(2000). Miltefosine for Visceral Leishmaniasis. NEJM
342: 894-895
[Full Text]
(2000). Miltefosine: Oral Therapy for Kala-Azar at Last?. JWatch Infect. Diseases
2000: 10-10
[Full Text]
Hanus, L., Abu-Lafi, S., Fride, E., Breuer, A., Vogel, Z., Shalev, D. E., Kustanovich, I., Mechoulam, R.
(2001). 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc. Natl. Acad. Sci. USA
98: 3662-3665
[Abstract][Full Text]