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Previous Volume 341:1882-1890 December 16, 1999 Number 25 Next

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ABSTRACT

Background Empirical antiarrhythmic therapy has not reduced mortality among patients with coronary artery disease and asymptomatic ventricular arrhythmias. Previous studies have suggested that antiarrhythmic therapy guided by electrophysiologic testing might reduce the risk of sudden death.

Methods We conducted a randomized, controlled trial to test the hypothesis that electrophysiologically guided antiarrhythmic therapy would reduce the risk of sudden death among patients with coronary artery disease, a left ventricular ejection fraction of 40 percent or less, and asymptomatic, unsustained ventricular tachycardia. Patients in whom sustained ventricular tachyarrhythmias were induced by programmed stimulation were randomly assigned to receive either antiarrhythmic therapy, including drugs and implantable defibrillators, as indicated by the results of electrophysiologic testing, or no antiarrhythmic therapy. Angiotensin-converting–enzyme inhibitors and beta-adrenergic–blocking agents were administered if the patients could tolerate them.

Results A total of 704 patients with inducible, sustained ventricular tachyarrhythmias were randomly assigned to treatment groups. Five-year Kaplan–Meier estimates of the incidence of the primary end point of cardiac arrest or death from arrhythmia were 25 percent among those receiving electrophysiologically guided therapy and 32 percent among the patients assigned to no antiarrhythmic therapy (relative risk, 0.73; 95 percent confidence interval, 0.53 to 0.99), representing a reduction in risk of 27 percent. The five-year estimates of overall mortality were 42 percent and 48 percent, respectively (relative risk, 0.80; 95 percent confidence interval, 0.64 to 1.01). The risk of cardiac arrest or death from arrhythmia among the patients who received treatment with defibrillators was significantly lower than that among the patients discharged without receiving defibrillator treatment (relative risk, 0.24; 95 percent confidence interval, 0.13 to 0.45; P<0.001). Neither the rate of cardiac arrest or death from arrhythmia nor the overall mortality rate was lower among the patients assigned to electrophysiologically guided therapy and treated with antiarrhythmic drugs than among the patients assigned to no antiarrhythmic therapy.

Conclusions Electrophysiologically guided antiarrhythmic therapy with implantable defibrillators, but not with antiarrhythmic drugs, reduces the risk of sudden death in high-risk patients with coronary disease.

Source Information

From the Department of Medicine, Brown University School of Medicine and Rhode Island Hospital, Providence (A.E.B.); Duke University Clinical Research Institute, Durham, N.C. (K.L.L., G.H.); the Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, N.Y. (J.D.F.); the Department of Medicine, Beth Israel Deaconess Medical Center, Boston (M.E.J.); and Care Group, Indianapolis (E.N.P.).

Address reprint requests to Dr. Buxton at the Division of Cardiology, Rhode Island Hospital, 2 Dudley St., Suite 360, Providence, RI 02905.

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Prevention of Sudden Death in Patients with Coronary Artery Disease
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Extract | Full Text  
N Engl J Med 2000; 342:1291-1292, Apr 27, 2000. Correspondence

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• Mittal, S. (2008). Selecting Patients for an Implantable Cardioverter-Defibrillator: Can the Genie Be Put Back Into the Bottle?. J Am Coll Cardiol 51: 297-299 [Full Text]  
• Anstadt, M. P., Lowe, J. E. (2008). Cardiopulmonary Resuscitation. Card Surg Adult 3: 487-506 [Full Text]  
• Spotnitz, H. M. (2008). Surgical Implantation of Pacemakers and Automatic Defibrillators. Card Surg Adult 3: 1395-1428 [Full Text]  
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• Rossenbacker, T., Priori, S. G., Zipes, D. P. (2007). The fight against sudden cardiac death: consensus guidelines as a reference. Eur Heart J Suppl 9: I50-I58 [Abstract] [Full Text]  
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• Almendral, J., Josephson, M. E. (2007). All Patients With Hemodynamically Tolerated Postinfarction Ventricular Tachycardia Do Not Require an Implantable Cardioverter-Defibrillator. Circulation 116: 1204-1212 [Full Text]  
• Faber, T. S., Gradinger, R., Treusch, S., Morkel, C., Brachmann, J., Bode, C., Zehender, M., for the EVENTS Investigators, (2007). Incidence of ventricular tachyarrhythmias during permanent pacemaker therapy in low-risk patients results from the German multicentre EVENTS study. Eur Heart J 28: 2238-2242 [Abstract] [Full Text]  
• Authors/Task Force Members, , Vardas, P. E., Auricchio, A., Blanc, J.-J., Daubert, J.-C., Drexler, H., Ector, H., Gasparini, M., Linde, C., Morgado, F. B., Oto, A., Sutton, R., Trusz-Gluza, M., ESC Committee for Practice Guidelines (CPG), , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Funck-Brentano, C., Filippatos, G., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., Document Reviewers, , Priori, S. G., Blomstrom-Lundqvist, C., Brignole, M., Terradellas, J. B., Camm, J., Castellano, P., Cleland, J., Farre, J., Fromer, M., Le Heuzey, J.-Y., Lip, G. Y., Merino, J. L., Montenero, A. S., Ritter, P., Schalij, M. J., Stellbrink, C. (2007). Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in Collaboration with the European Heart Rhythm Association. Eur Heart J 28: 2256-2295 [Full Text]  
• England, R., England, T., Coggon, J. (2007). The ethical and legal implications of deactivating an implantable cardioverter-defibrillator in a patient with terminal cancer. J. Med. Ethics 33: 538-540 [Abstract] [Full Text]  
• Stephenson, E. A., Berul, C. I. (2007). Electrophysiological Interventions for Inherited Arrhythmia Syndromes. Circulation 116: 1062-1080 [Full Text]  
• Ezekowitz, J. A., Rowe, B. H., Dryden, D. M., Hooton, N., Vandermeer, B., Spooner, C., McAlister, F. A. (2007). Systematic Review: Implantable Cardioverter Defibrillators for Adults with Left Ventricular Systolic Dysfunction. ANN INTERN MED 147: 251-262 [Abstract] [Full Text]  
• Bruch, C., Bruch, C., Sindermann, J., Breithardt, G., Gradaus, R. (2007). Prevalence and prognostic impact of comorbidities in heart failure patients with implantable cardioverter defibrillator. Europace 9: 681-686 [Abstract] [Full Text]  
• Yap, Y. G., Duong, T., Bland, J M., Malik, M., Torp-Pedersen, C., Kober, L., Gallagher, M. M, Camm, A J. (2007). Optimising the dichotomy limit for left ventricular ejection fraction in selecting patients for defibrillator therapy after myocardial infarction. Heart 93: 832-836 [Abstract] [Full Text]  
• Chugh, S. S., Reinier, K., Stecker, E. C. (2007). Learning From a Real-World Analysis of Implantable Cardioverter-Defibrillator Recipients: Comorbidities Matter. J Am Coll Cardiol 49: 2416-2418 [Full Text]  
• Bunch, T. J., Hohnloser, S. H., Gersh, B. J. (2007). Mechanisms of Sudden Cardiac Death in Myocardial Infarction Survivors: Insights From the Randomized Trials of Implantable Cardioverter-Defibrillators. Circulation 115: 2451-2457 [Full Text]  
• Zimetbaum, P. J. (2007). A 59-Year-Old Man Considering Implantation of a Cardiac Defibrillator. JAMA 297: 1909-1916 [Abstract] [Full Text]  
• Ermis, C., Zhu, A. X., VanHeel, L., Sakaguchi, R.N. S., Lurie, K. G., Lu, F., Benditt, D. G. (2007). Comparison of ventricular arrhythmia burden, therapeutic interventions, and survival, in patients < 75 and patients >= 75 years of age treated with implantable cardioverter defibrillators. Europace 9: 270-274 [Abstract] [Full Text]  
• Goldenberg, I., Moss, A. J., McNitt, S., Zareba, W., Hall, W. J., Andrews, M. L., for the MADIT-II Investigators, (2007). Inverse Relationship of Blood Pressure Levels to Sudden Cardiac Mortality and Benefit of the Implantable Cardioverter-Defibrillator in Patients With Ischemic Left Ventricular Dysfunction. J Am Coll Cardiol 49: 1427-1433 [Abstract] [Full Text]  
• Epstein, A. E., Baessler, C. A., Curtis, A. B., Estes, N.A. M. III, Gersh, B. J., Grubb, B., Mitchell, L. B. (2007). Addendum to "Personal and Public Safety Issues Related to Arrhythmias That May Affect Consciousness: Implications for Regulation and Physician Recommendations: A Medical/ Scientific Statement From the American Heart Association and the North American Society of Pacing and Electrophysiology" Public Safety Issues in Patients With Implantable Defibrillators A Scientific Statement From the American Heart Association and the Heart Rhythm Society. Circulation 115: 1170-1176 [Abstract] [Full Text]  
• Bailey, J. J., Hodges, M., Church, T. R. (2007). Decision to Implant a Cardioverter Defibrillator after Myocardial Infarction: The Role of Ejection Fraction v. Other Risk Factor Markers. Med Decis Making 27: 151-160 [Abstract]  
• Camm, J., Klein, H., Nisam, S. (2007). The cost of implantable defibrillators: perceptions and reality. Eur Heart J 28: 392-397 [Abstract] [Full Text]  
• Lindenfeld, J., Feldman, A. M., Saxon, L., Boehmer, J., Carson, P., Ghali, J. K., Anand, I., Singh, S., Steinberg, J. S., Jaski, B., DeMarco, T., Mann, D., Yong, P., Galle, E., Ecklund, F., Bristow, M. (2007). Effects of Cardiac Resynchronization Therapy With or Without a Defibrillator on Survival and Hospitalizations in Patients With New York Heart Association Class IV Heart Failure. Circulation 115: 204-212 [Abstract] [Full Text]  
• Dzau, V. J., Antman, E. M., Black, H. R., Hayes, D. L., Manson, J. E., Plutzky, J., Popma, J. J., Stevenson, W. (2006). The Cardiovascular Disease Continuum Validated: Clinical Evidence of Improved Patient Outcomes: Part II: Clinical Trial Evidence (Acute Coronary Syndromes Through Renal Disease) and Future Directions. Circulation 114: 2871-2891 [Full Text]  
• Davis, D. R., Tang, A. S.L., Lemery, R., Green, M. S., Gollob, M. H., Birnie, D. H. (2006). Influence of gender on ICD implantation for primary and secondary prevention of sudden cardiac death. Europace 8: 1054-1056 [Abstract] [Full Text]  
• Chan, P. S., Chow, T., Kereiakes, D., Schloss, E. J., Waller, T., Eagle, K., Hayward, R. A., Vijan, S. (2006). Effectiveness of implantable cardioverter-defibrillators in patients with ischemic heart disease and left ventricular dysfunction.. Arch Intern Med 166: 2228-2233 [Abstract] [Full Text]  
• Kaufman, E. S., Bloomfield, D. M., Steinman, R. C., Namerow, P. B., Costantini, O., Cohen, R. J., Bigger, J. T. Jr (2006). "Indeterminate" Microvolt T-Wave Alternans Tests Predict High Risk of Death or Sustained Ventricular Arrhythmias in Patients With Left Ventricular Dysfunction. J Am Coll Cardiol 48: 1399-1404 [Abstract] [Full Text]  
• Occhetta, E., Bortnik, M., Magnani, A., Francalacci, G., Marino, P. (2006). Inappropriate implantable cardioverter-defibrillator discharges unrelated to supraventricular tachyarrhythmias. Europace 8: 863-869 [Abstract] [Full Text]  
• Gheorghiade, M., Sopko, G., De Luca, L., Velazquez, E. J., Parker, J. D., Binkley, P. F., Sadowski, Z., Golba, K. S., Prior, D. L., Rouleau, J. L., Bonow, R. O. (2006). Navigating the Crossroads of Coronary Artery Disease and Heart Failure. Circulation 114: 1202-1213 [Full Text]  
• Muller, D., Agrawal, R., Arntz, H.-R. (2006). How Sudden Is Sudden Cardiac Death?. Circulation 114: 1146-1150 [Abstract] [Full Text]  
• Developed in Collaboration With the European Heart, , Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L. (2006). ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 48: 1064-1108 [Full Text]  
• Developed in Collaboration With the European Heart, , Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L. (2006). ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 48: e247-e346 [Full Text]