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Previous Volume 341:1935-1937 December 16, 1999 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Copel, J. A. Related Article by Wald, N.J. Related Article by Wald, N.J. PubMed Citation

To the Editor: Wald et al. (Aug. 12 issue)¹ describe a protocol for screening for Down's syndrome that is based on tests performed during both the first and second trimesters of pregnancy. However, their estimates are based on data from multiple studies, some rather small. Most important, they fail to consider the advantages of a diagnosis in the first trimester.

Chorionic-villus sampling in the first trimester and amniocentesis in the second trimester are equally effective and safe procedures with similar rates of procedure-induced loss at experienced centers.^2,3 Total loss rates after chorionic-villus sampling are higher because of the higher rate . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Wald, N., Members of the FASTER Trial Research Consortium, , Chasen, S. T., Skupski, D. W., Chervenak, F. A., McCullough, L. B. (2002). First-Trimester Nuchal Translucency Screening. J Ultrasound Med 21: 481-487 [Full Text]