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Previous Volume 341:198-203 July 15, 1999 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Successful clinical research depends on the ability to recruit research subjects. Tension between the need to recruit subjects and the obligation to offer them certain types of protection has made recruitment a persistent ethical challenge. One important and difficult issue involves whom investigators should enroll in research studies. A different but equally crucial issue concerns the types of inducement investigators should use to recruit subjects.

For decades, many investigators have paid subjects for participating in research studies, and this practice remains one of the most controversial methods of recruitment.¹ Despite discussions over many years, ethical issues about payment remain unresolved. . . . [Full Text of this Article]

Paying Patients or Healthy Subjects

Three Models of Payment

The Market Model

The Wage-Payment Model

The Reimbursement Model

Applying the Models to a Case

Advantages and Disadvantages of Each Model

The Model of Choice: Wage Payment

Conclusions

References

Related Letters:

What's the Price of a Research Subject?
Saunders C. A., Sugar A. M., Thompson P. D., Weijer C., Yaes R. J., Dickert N., Grady C.
Extract | Full Text  
N Engl J Med 1999; 341:1550-1552, Nov 11, 1999. Correspondence

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